Fritz F. Pan

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One mechanism that could block transcription of the ER gene in ER-negative breast cancers without structural alteration in the gene is methylation of cytosine-rich areas, termed â€oeCpG islands,†• in the 5' regulatory region of the gene (9). CpG islands are always unmethylated in normal adult tissues, with the exception of tran scriptionally silent genes(More)
Intravenous immunoglobulin (IVIg) is a blood product with immunomodulating properties that have been widely applied in the management of renal transplant recipients. In general, IVIg has been considered a relatively safe therapy, with most adverse events being mild and transient. Although rare, a serious and well-recognized complication of IVIg is(More)
One mechanism that could block transcription of the ER gene in ER-negative breast cancers without structural alteration in the gene is methylation of cytosine-rich areas, termed “CpGislands,―in the 5' regulatory region of the gene (9). CpG islands are always unmethylated in normal adult tissues, with the exception of tran scriptionally silent genes on(More)
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