Fritz Anders

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Modern cancerology is based on the oncogene concept. This is rather new. The idea of the oncogene, however, is old, and can be traced back to two sources, namely to "cancer families," reported in 1866 by P. Broka, and to "virus induced" neoplasia, detected by P. Rous in 1911. A gene which is--to my knowledge--the first reported oncogene by definition was(More)
Linkage between an autosomal regulatory gene Diff controlling differentiation of neoplastic melanophores and an esterase locus, Est-1, has been demonstrated in Xiphophorus. The recombination values between Est-1 and Diff ranged from 21 to 29 percent depending on the melanophore pattern loci Sp, Sd, Sd, and Livar. The average recombination frequency for all(More)
The worldwide accelerating increase of neoplasia in humans is difficult to explain. We use the Xiphophorus tumor model to approach this problem by melanoma provocation with X-rays. Melanoma develops following inappropriate expression of x-erb B-conducted developmental genes and their controllers. These oncodeterminants are inherited according to Mendelian(More)
Bei bestimmten Zahnkarpfen-Bastarden treten stets erbbedingte Melanome auf. Diese entstehen dadurch, dass bestimmte Gene, die für die Differenzierung von Farbzellen verantwortlich sind, enthemmt und gleichzeitig zu einer gesteigerten Aktivität angeregt werden. Die Enthemmung beruht auf einem Verlust bestimmter Repressionsgene und die Aktivitätssteigerung(More)
INTRODUCTION In 65 genotypes of Xiphophorus (nonhybnids and inter populational and interspecific F and backcnoss hybrids), the susceptibility to neuroblastoma following treatment with carcinogenic-mutagenic agents was tested. The fish were exposed to an aqueous solution of N-methyl-N-n itro sounea (MNU) or exposed to X-rays. Neunoblastoma was induced by MNU(More)
DNA polymerases have been isolated from muscle and melanoma tissues of Xiphophorus, which are similar to retroviral RNA-dependent DNA polymerases as they prefer RNA to DNA templates. They appear to associate with submicroscopic structures which exhibit a density of about 1.13 g/ml after sucrose-density-gradient centrifugation. The(More)
Certain genotypes of Xiphophorus harbour an accessory Mendelian gene which following loss, impairment, or insufficiency of its regulatory genes in the germ line, mediates the hereditary capacity to develop neoplasia spontaneously or following induction with initiating and promoting carcinogens. Together with its linked regulatory genes it forms a 'tumor(More)
Southern blot analyses of the xiphophorine genome with probes specific for 15 viral and cellular oncogenes revealed that only three v-erbB related EcoRI fragments comprising 4.9 kb of a certain X, 11.5 kb of another X, and 6.7 kb of both a Y and a Z chromosome are inherited in parallel with the Tu complex and melanoma formation. They are accessory in the(More)