Frithjof Weber

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This study has investigated the effects of herpes simplex thymidine kinase gene (HSV-tk) transfer followed by ganciclovir treatment as adjuvant gene therapy to surgical resection in patients with recurrent glioblastoma multiforme (GBM). The study was open and single-arm, and aimed at assessing the feasibility and safety of the technique and indications of(More)
This paper aims to describe the main barriers to knowledge sharing in the extended enterprise. The barriers were identified through a literature review and work with industrial companies. The barriers have been categorised according to the TOP (Technology, Organisation, People) classification. The main finding is that the majority of barriers are concerned(More)
PURPOSE This was an open-label, dose-escalation trial of intratumoral administration of IL-4 Pseudomonas Exotoxin (NBI-3001) in patients with recurrent malignant glioma. PATIENTS AND METHODS A total of 31 patients with histologically verified supratentorial grade 3 and 4 astrocytoma were studied. Of these, twenty-five patients were diagnosed with(More)
Somatic gene therapy with the herpes simplex virus type I thymidine kinase gene/ganciclovir (HSV-Tk/GCV) system and murine retroviral vector producer cells (VPCs) was introduced as a new adjuvant treatment modality to treat tumor bulk and to prevent tumor recurrence in patients harboring malignant glioma. The single-center experience after treatment of 27(More)
In our search for a more versatile protecting group that would exhibit fast release rates for peptides, we have designed and developed the p-hydroxyphenacyl (pHP) group as a new photoremovable protecting group. We report the application of this protecting group for the dipeptide Ala-Ala (1) and for the nonapeptide bradykinin (2), two representative peptides(More)
The paper will present results from investigations, consultations and workshops from the European KM Forum which is aiming to identify and support commonality in KM terminology, application and implementation in Europe. The paper discuss the relevance of standardisation for a soft and holistic subject like KM by synthesising the major opinions from the KM(More)
This paper proposes a human-centred solution framework for KM in the Concurrent Enterprise. The framework allows for the identification of key prerequisites and enablers for inter-organisational knowledge management. In the end the framework provides a theoretically based check-list to assess inter-organisational co-operations towards their knowledge(More)
BACKGROUND AND PURPOSE Our goal was to evaluate MR imaging findings after local intracerebral gene therapy in patients with glioblastoma and differentiate postoperative contrast enhancement phenomena. METHODS In all, 26 patients with supratentorial single lesion glioblastoma underwent tumor resection and intracerebral injection of murine retroviral(More)
The morphologic pattern of contrast enhancement in magnetic resonance imaging (MRI) of glioblastoma patients could be non specific and metabolic investigations can be useful for the differentiation of tumorous and non tumorous enhancement. Following initial therapy secondary tissue changes can occur and non specific non tumorous enhancement phenomena have(More)