Friedrich Wimazal

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New insights into the prognostic impact of the karyotype in MDS and correlation with subtypes: evidence from a core dataset of 2124 patients.

Detlef Haase, Ulrich Germing, +16 authors Christian Steidl
Blood
2007

We have generated a large, unique database that includes morphologic, clinical, cytogenetic, and follow-up data from 2124 patients with myelodysplastic syndromes (MDSs) at 4 institutions in Austria… (More)

Prognostic significance of serial determinations of lactate dehydrogenase (LDH) in the follow-up of patients with myelodysplastic syndromes.

Friedrich Wimazal, Wolfgang R Sperr, +5 authors Paul Valent
Annals of oncology : official journal of the…
2008

BACKGROUND Early recognition of disease progression in low-risk myelodysplastic syndromes (MDS) is an important decision point concerning intensive therapies. In a screen program searching for… (More)

Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: Monoclonal mast cell activation syndrome.

Karoline Sonneck, Stefan Ioan Florian, +4 authors Peter Valent
International archives of allergy and immunology
2007

BACKGROUND Patients with mastocytosis may suffer from severe hypotension after wasp or bee stings. In these patients, no specific IgE is detectable, but they usually have skin lesions and an elevated… (More)

Iron overload in myelodysplastic syndromes (MDS) – diagnosis, management, and response criteria: a proposal of the Austrian MDS platform

Peter Valent, O. v. Krieger, +6 authors Michael Pfeilstoecker
European journal of clinical investigation
2008

Transfusion-related morbidity is an emerging challenge in chronically transfused patients with low-risk myelodysplastic syndromes (MDS). In these patients, transfusion-induced iron overload may… (More)

Idiopathic cytopenia of undetermined significance (ICUS) versus low risk MDS: the diagnostic interface.

Friedrich Wimazal, Christa Fonatsch, +5 authors Peter Valent
Leukemia research
2007

It may sometimes be difficult to diagnose low risk MDS in patients with mild cytopenia. We report on 10 patients with mild to marked, unexplained cytopenia without definitive signs of a myeloid… (More)

Increased angiogenesis in the bone marrow of patients with systemic mastocytosis.

Friedrich Wimazal, John-Hendrik Jordan, +5 authors Peter Valent
The American journal of pathology
2002

Recent data suggest that angiogenesis in the bone marrow (BM) is augmented and associated with growth of neoplastic cells in various hematological malignancies. Systemic mastocytosis (SM) is a… (More)

Prognostic value of lactate dehydrogenase activity in myelodysplastic syndromes.

Friedrich Wimazal, Wolfgang R Sperr, +8 authors Peter Valent
Leukemia research
2001

Several prognostic factors for patients with myelodysplastic syndromes (MDS) have been defined in the past. One of these factors appears to be the serum lactate dehydrogenase (LDH) activity. However,… (More)

The KIT D816V allele burden predicts survival in patients with mastocytosis and correlates with the WHO type of the disease.

Gregor Hoermann, Karoline V. Gleixner, +8 authors Wolfgang R Sperr
Allergy
2014

KIT D816V is present in a majority of patients with systemic mastocytosis (SM). We determined the KIT D816V allele burden by quantitative real-time PCR in bone marrow and peripheral blood of 105… (More)

Serum tryptase measurements in patients with myelodysplastic syndromes.

Wolfgang R Sperr, B Stehberger, +13 authors Peter Valent
Leukemia & lymphoma
2002

Abnormal differentiation and maturation of hemopoietic cells are characteristic features of myelodysplastic syndromes (MDS). Tryptases (alpha- and beta-type) are lineage-restricted serine proteases… (More)

Eosinophilia in systemic mastocytosis: clinical and molecular correlates and prognostic significance.

Alexandra Boehm, Manuela Födinger, +5 authors Peter Valent
The Journal of allergy and clinical immunology
2007

BACKGROUND In a group of patients with systemic mastocytosis (SM), marked and sustained eosinophilia is detectable (SM-eo). OBJECTIVE Although the molecular defect has been defined in some cases,… (More)

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