Learn More
The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative development and widespread use of innovative software, reducing barriers to entry into interdisciplinary scientific research, and promoting the achievement of(More)
Papers published in this report series are preliminary versions of journal articles. Abstract This paper introduces ideas and methods for testing for structural change in linear regression models and presents how these have been realized in an R package called strucchange 1. It features tests from the generalized fluctuation test framework as well as from(More)
This article is a (slightly) modified version of Grün and Leisch (2008b), published in the Journal of Statistical Software. flexmix provides infrastructure for flexible fitting of finite mixture models in R using the expectation-maximization (EM) algorithm or one of its variants. The functionality of the package was enhanced. Now concomitant variable models(More)
This article was originally published as Leisch (2004b) in the Journal of Statistical Software. FlexMix implements a general framework for fitting discrete mixtures of regression models in the R statistical computing environment: three variants of the EM algorithm can be used for parameter estimation, regressors and responses may be multivariate with(More)
A methodological and computational framework for centroid-based partitioning cluster analysis using arbitrary distance or similarity measures is presented. The power of high-level statistical computing environments like R enables data analysts to easily try out various distance measures with only minimal programming effort. A new variant of centroid(More)
In this paper we introduce the generalized fluctuation test for monitoring structural changes and establish a result characterizing the limiting behavior of this class of tests+ As applications of the generalized fluctuation test, tests based on the maximum and range of the fluctuation of moving estimates are proposed+ We also derive the boundary functions(More)
BACKGROUND Despite the widely accepted view that schizophrenia and bipolar disorder represent independent illnesses and modes of inheritance, some data in the literature suggest that the diseases may share some genetic susceptibility. The objective of our analyses was to search for vulnerability loci for the two disorders. METHODS A genomewide map of 388(More)
Serotonergic mechanisms are thought to play an important role in the pathogenesis of seasonal affective disorder (SAD). The expression of the serotonin transporter (5-HTT) is regulated in part by an insertion/deletion polymorphism in the serotonin transporter gene promoter region (5-HTTLPR). The 5-HTTLPR short allele (s) has been associated with(More)