Friedrich Hoffmann

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The Frog Embryo Teratogenesis Assay--Xenopus (FETAX) was used to assess the teratogenic potential of four solvents. Embryos of the South African clawed frog, Xenopus laevis, were exposed for 96 h to ethanol, dimethyl sulfoxide (DMSO), formamide or glycerol formal. Exposure groups were maintained using a static renewal system in which the exposure media were(More)
This study describes the use of a panel of immune assays, originally developed by the National Toxicology Program for assessing xenobiotic-induced immunotoxicity in mice, to quantify the effects of sublethal malathion exposure on the immune responses of fish. For this study, Japanese medaka (Oryzias latipes) were exposed subchronically to the(More)
Cyclosporin A (CS-A), selectively inhibited cellular immunity, delayed the skin graft-induced rejection of corneal allografts in rabbits when administered subconjunctivally in the dose of 3 mg/kg/day or in the form of 5% water-soluble drops five times daily for 28 days. The subconjunctival application of CS-A was irritating, whereas the topical instillation(More)
OBJECTIVES To study the ultrastructure of the trabecular meshwork in human eyes with corticosteroid-induced glaucoma and to determine whether the changes noted also occur in the eyes of patients with primary open-angle glaucoma (POAG) who have been treated with corticosteroids. METHODS The trabecular meshwork from 5 patients in whom corticosteroid-induced(More)
Three tick-sampling methods (dry ice-baited tick traps, cloth drags, and ambulatory human host) were evaluated to determine which technique yielded the greatest capture of host-seeking stages of Ixodes dammini Spielman, Clifford, Piesman & Corwin and Amblyomma americanum (L.). The most reliable method, catching more stages and significantly more numbers of(More)
• Background: The murine model of orthotopic perforating keratoplasty is important for studying the allograft reaction, but the small dimensions cause technical difficulties. • Methods: The anterior chamber of the eye of the BALB/c mouse was measured with the confocal microscope and with histological methods. Ten C3H mouse donor corneas each were separated(More)
Background: Experiments were performed to determine whether corneal epithelium transfected with minimalistic immunologically defined expression constructs for the extracellular fragment of CTLA4 and for interleukin-4 (IL-4) or interleukin-10 (IL-10) is able to modulate an allospecific immune response after orthotopic corneal grafting in mice. Methods: Six(More)
  • F Hoffmann
  • Klinische Monatsblätter für Augenheilkunde
  • 1976
The usual suture techniques in connection with perforating keratoplasty and the pulling direction of the threads are described. Especially unfavorable are the verticle factors with relation to the radial and diagonal continuous suture, which necessarily lead to a gaping of the inner and outer wound fissure. The double continuous diagonal suture(More)
Lebensbedrohliche Ereignisse im Kindesalter sind seltene aber gefürchtete Einsatzindikationen im Notarztdienst. Das Erkennen des kritisch kranken Kindes und die rasche Therapie von respiratorischer und kardiozirkulatorischer Dekompensation bestimmen bei diesen Patienten wesentlich die Prognose. Durch rechtzeitige Intervention kann eine Reanimationssituation(More)