Manual segmentation is often used for evaluation of automatic or semi-automatic segmentation. The purpose of this paper is to describe the inter and intraindividual variability, the dubiety of manual segmentation as a gold standard and to find reasons for the discrepancy. We realized two experiments. In the first one ten ENT surgeons, ten medical students… (More)
BACKGROUND Mesenchymal stem cells (MSCs) participate in the regulation of inflammation and innate immunity, for example by responding to pathogen-derived signals and by regulating the function of innate immune cells. MSCs from the bone-marrow and peripheral tissues share common basic cell-biological functions. However, it is unknown whether these MSCs… (More)
OBJECTIVES The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells. Recently, amplification of the SOX2 gene locus has been described in squamous cell carcinoma (SCC) of different organ sites. Aim of this study was to investigate amplification and… (More)
We present a model-driven approach to the segmentation of nasal cavity and paranasal sinus boundaries. Based on computed tomog-raphy data of a patients head, our approach aims to extract the border that separates the structures of interest from the rest of the head. This three-dimensional region information is useful in many clinical applications , e.g.… (More)
AIM To test laser scanning cytometry (LSC) for the analysis of ploidy in squamous cell carcinoma of the hypopharynx (SCCH) and to develop a routine application for minimal samples such as fine needle aspirate biopsies (FNABs). METHODS From 11 individuals 30 FNABs of primary tumors (n=11) and lymphatic metastases of SCCH (n=11) and non-metastatic lymph… (More)
— In this video we show our current prototype for robot assisted endoscopy. The system requires only few and simple instructions from the surgeon, in order to guide the endoscope in an intelligent, autonomous, and safe way: The surgeon tells what to do and the robot decides how to carry out the task by choosing the best manipulation primitive in every… (More)
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