Friedrich Bootz

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Segmentation of medical image data is getting more and more important over the last years. The results are used for diagnosis, surgical planning or workspace definition of robot-assisted systems. The purpose of this paper is to find out whether manual or semi-automatic segmentation is adequate for ENT surgical workflow or whether fully automatic(More)
Manual segmentation of computed tomography (CT) datasets was performed for robot-assisted endoscope movement during functional endoscopic sinus surgery (FESS). Segmented 3D models are needed for the robots' workspace definition. A total of 50 preselected CT datasets were each segmented in 150-200 coronal slices with 24 landmarks being set. Three different(More)
Functional Endoscopic Surgery of Paranasal sinuses (FESS) and Skull Base surgery is one of the most frequent surgeries performed at the ENT department of the Bonn University, Germany. Beside of surgical Navigation Robotic is one of the upcoming fields of Computer assisted Surgery developments. This work presents novel research and concepts for Robot(More)
BACKGROUND Mesenchymal stem cells (MSCs) participate in the regulation of inflammation and innate immunity, for example by responding to pathogen-derived signals and by regulating the function of innate immune cells. MSCs from the bone-marrow and peripheral tissues share common basic cell-biological functions. However, it is unknown whether these MSCs(More)
Manual segmentation is often used for evaluation of automatic or semi-automatic segmentation. The purpose of this paper is to describe the inter and intraindividual variability, the dubiety of manual segmentation as a gold standard and to find reasons for the discrepancy. We realized two experiments. In the first one ten ENT surgeons, ten medical students(More)
The main disadvantage of conventional functional endoscopic sinus surgery (FESS) for the surgeon is the restriction to one hand for manipulation while the other hand is holding the endoscope. In our project we develop an automatic anticipating robot assisted endoscope guidance during FESS. The robot guidance will be realized by a multisensor system which(More)
OBJECTIVES The transcription factor SOX2 (3q26.3-q27) is an embryonic stem cell factor contributing to the induction of pluripotency in terminally differentiated somatic cells. Recently, amplification of the SOX2 gene locus has been described in squamous cell carcinoma (SCC) of different organ sites. Aim of this study was to investigate amplification and(More)
In this video we show our current prototype for robot assisted endoscopy. The system requires only few and simple instructions from the surgeon, in order to guide the endoscope in an intelligent, autonomous, and safe way: The surgeon tells what to do and the robot decides how to carry out the task by choosing the best manipulation primitive in every control(More)
Otoacoustic emissions (OAE) are influenced in their amplitude and frequency spectra by the middle ear. The effects of changes in the middle ear transmission mechanisms on transiently evoked OAE (TEOAE) and distortion product emissions (DPOAE) were investigated as a function of static ear canal pressure in 25 normal-hearing test persons aged 18-35 years. The(More)