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Transcranial stimulation in man evokes multiple descending volleys in the spinal cord giving rise to multiple subpeaks in a peri-stimulus-time histogram (PSTH) obtained from a cross-correlation of motor unit discharges with transcranial stimuli. The first volley is termed the D wave, as it is assumed to be evoked by direct excitation of pyramidal tract(More)
Short-interval, paired-pulse transcranial magnetic stimulation (TMS) is usually used to demonstrate intracortical inhibition. It was shown recently that with short-interval, paired-pulse TMS a facilitation - called intracortical I-wave facilitation - can also be demonstrated. It was the aim of this study to investigate which stimulus conditions lead to(More)
There are several parameters associated with motoneuron size, among which are the conduction velocity of the axon as well as the size of the excitatory postsynaptic potential (EPSP) induced by stimulation of Ia afferents in the corresponding muscle nerve. In particular, it has been established in animal experiments that small motoneurons with a low(More)
According to the size principle for motoneurons one would expect that an excitatory stimulus given to a motoneuronal pool should evoke small excitatory postsynaptic potentials (EPSPs) in large and large EPSPs in small motoneurons of the pool. In this study this expectation was tested for the motoneuron pool of the first dorsal interosseus muscle of man(More)
The purpose of this study was to investigate the influence of different angles of the knee joint on voluntary activation of the quadriceps muscle, estimating the ability of a subject to activate a muscle maximally by means of voluntary contraction. Isometric torque measurement was performed on 6 healthy subjects in 5 degrees intervals between 30 degrees and(More)
Procedures for the analysis of stimulus-correlated spike train data are reviewed. All procedures considered attempt to extract excitability changes evoked by the stimulus at the neuron investigated. The methods covered range from rather simple methods that require very little computational effort (raw spike train displays; peri-stimulus-time histogram(More)
Several ways of estimating a continuous function from the spike train output of a neuron subjected to repeated stimuli are compared: (i) the probability of firing function estimated by a PST-histogram (ii) the rate of discharge function estimated by a "frequencygram" (Bessou et al. 1968) and (iii) the interspike-interval function which is introduced in this(More)
Adding a potassium permeability with slow kinetics to the Frankenhaeuser-Huxley equations describing action potential generation at a frog node of Ranvier has a twofold effect on the maintained repetitive firing the model can show. If the contribution of the slow to the total potassium permeability is increased, the maintained discharge frequency for a(More)
OBJECTIVE Late-onset Pompe disease is a slowly progressive disorder resulting from deficiency of lysosomal acid alpha-glucosidase (GAA). Since 2006, an intravenous enzyme replacement therapy (ERT) with Myozyme™ (alglucosidase alfa) is available but long-term experience with ERT in late-onset Pompe disease is still limited. METHODS Two adult patients with(More)