Friedemann Awiszus

Learn More
PURPOSE The inability to fully activate the quadriceps femoris muscle voluntarily is known to accompany several different knee-joint pathologies. The extent of a voluntary-activation deficit in patients after isolated rupture of the anterior cruciate ligament (ACL), however, has been reported to be small or nonexistent, making it questionable if a(More)
The purpose of this study was to investigate the influence of different angles of the knee joint on voluntary activation of the quadriceps muscle, estimating the ability of a subject to activate a muscle maximally by means of voluntary contraction. Isometric torque measurement was performed on 6 healthy subjects in 5 degrees intervals between 30 degrees and(More)
Short-interval, paired-pulse transcranial magnetic stimulation (TMS) is usually used to demonstrate intracortical inhibition. It was shown recently that with short-interval, paired-pulse TMS a facilitation – called intracortical I-wave facilitation – can also be demonstrated. It was the aim of this study to investigate which stimulus conditions lead to(More)
Central activation deficits have been recognised to be partially responsible for quadriceps muscle weakness after knee injuries effecting the injured as well as the uninjured leg. The purpose of this study was to assess the extent of bilateral activation deficits and its effect on functional muscle tests using the uninjured leg as reference. The study(More)
The peri-stimulus-time histogram (PSTH) analysis of stimulus-related neuronal spike train data is usually regarded as a method to detect stimulus-induced excitations or inhibitions. However, for a fairly regularly discharging neuron such as the human α-motoneuron, long-latency modulations of a PSTH are difficult to interpret as PSTH modulations can also(More)
The loss of full muscle activation contributes to weakness of the quadriceps muscle in patients with deficiency of the anterior cruciate ligament (ACL). We examined whether a deficit of voluntary activation (VA) of the quadriceps muscle can be reversed by reconstruction of the ACL and assessed its influence on muscle strength and clinical parameters. We(More)
Neuronal output properties for input stimuli that evoke a deterministic response can be efficiently described by the interspike-interval function (Awiszus 1988a). It is shown in this paper that there are stimuli for which both the Hodgkin-Huxley (HH-) model of an action potential encoding membrane (Hodgkin and Huxley 1952) and a muscle spindle primary(More)
OBJECTIVE Late-onset Pompe disease is a slowly progressive disorder resulting from deficiency of lysosomal acid alpha-glucosidase (GAA). Since 2006, an intravenous enzyme replacement therapy (ERT) with Myozyme™ (alglucosidase alfa) is available but long-term experience with ERT in late-onset Pompe disease is still limited. METHODS Two adult patients with(More)
A Prospective randomised controlled study was done to determine statistical difference between the standard microsurgical discotomy (MC) and a minimally invasive microscopic procedure for disc prolapse surgery by comparing operation duration and clinical outcome. Additionally, the transferability of the results was determined by a bicentric design. The(More)