Fridrik E Yngvason

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A solid phase radioimmunoassay was devised for measuring the value of the carcinoma associated carbohydrate antigen CA 50 in serum based on the use of a specific monoclonal antibody (C 50). Samples of serum from 259 patients with carcinoma, 114 patients with other malignancies or inflammatory diseases, and 150 healthy controls were examined. Serum values of(More)
SETTING The clinical differences between cryptogenic organising pneumonia (COP) and secondary organising pneumonia (OP) have not been studied well. OBJECTIVE To compare clinical features in COP and secondary OP. DESIGN Causes, clinical features, treatment, radiographic studies and pathology were studied. RESULTS After re-evaluation, 104 patients(More)
With the aid of a highly specific murine monoclonal antibody, F12, an immunofluorescence method was elaborated that allowed sensitive and specific detection of the ganglioside antigen fucosyl-GM1 (IV2FucII3NeuAcGgOse4Cer) in different types of human lung cancer and normal tissues. Nineteen of 21 cases of small cell lung cancer were positive with the F12(More)
Monoclonal antibodies with an apparent specificity for fucosyl-GM1 (Fuc-GM1) were produced by the immunization of mice with Fuc-GM1 adsorbed to Salmonella minnesota bacteria and fusion of the spleen cells with the myeloma cell line Sp 2/0. The antibodies detected Fuc-GM1 with a unique ceramide composition containing 2-hydroxy fatty acids in 11 of 12 cases(More)
Many species of the Neisseria, gram-negative diplococci that are frequent respiratory commensals in humans, have been regarded as being nonpathogenic or as causing disease in only immunocompromised hosts; in contrast, gram-negative diplococci such as Neisseria meningitidis and Neisseria gonorrhoeae are known pathogens. We report a case in which Neisseria(More)
OBJECTIVE To investigate the incidence of sarcoidosis in Iceland, its clinical manifestations and potential environmental influences. MATERIALS AND METHODS All histopathological diagnoses of non-necrotizing granulomas generated in Iceland during the period 1981-2003 were reviewed with respect to a diagnosis of sarcoidosis. Further, patients were(More)
Characterization of monosialogangliosides of a small cell lung carcinoma showed a unique composition. The tumour contained GM2 and Fucosyl-GM1 (Fuc-GM1) with 2-hydroxy fatty acids as major ganglioside components. Three out of four other small cell carcinomas analysed contained also Fuc-GM1 as a characteristic ganglioside. Fuc-GM1 is suggested to be a(More)
BACKGROUND The purpose of this study was to estimate the value of the transferrin receptor in serum (sTfR) for detecting iron deficiency and compare it with the value of some other blood tests for that purpose. MATERIAL AND METHODS All patients undergoing bone marrow aspiration in the FSA Hospital, Akureyri, Iceland, in the period 1999 to 2003 were(More)
With the aid of a highly specific murine monoclonal antibody, F12, an immunofluorescence method was elaborated that allowed sensitive and specific detection of the ganglioside antigen fucosyl-GMi (IV2FucII3NeuAcGgOse4Cer) in different types of human lung cancer and normal tissues. Nineteen of 21 cases of small cell lung cancer were positive with the F12(More)
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