Fredrik Pettersson

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Pridopidine (ACR16) belongs to a new pharmacological class of agents affecting the central nervous system called dopaminergic stabilizers. Dopaminergic stabilizers act primarily at dopamine type 2 (D(2)) receptors and display state-dependent behavioural effects. This article aims to give an overview of the preclinical neurochemical and behavioural in vivo(More)
Software process improvement (SPI) is challenging, particularly for small and medium sized enterprises. Most existing SPI frameworks are either too expensive to deploy, or do not take an organizations' specific needs into consideration. There is a need for light weight SPI frameworks that enable practitioners to base improvement efforts on the issues that(More)
Two specific chromosome-targeting and gene regulatory systems are present in Drosophila melanogaster. The male X chromosome is targeted by the male-specific lethal complex believed to mediate the 2-fold up-regulation of the X-linked genes, and the highly heterochromatic fourth chromosome is specifically targeted by the Painting of Fourth (POF) protein,(More)
Turbo charged SI engines are a major possibility in the current trend of down-sized engines with preserved drivability performance. Considering control and supervision it is favorable to have a mean value model to be used e.g. in observer design. Such models of turbo engines are similar to those of naturally aspirated engines, but there are some special(More)
A new approach is presented for predicting ligand binding to proteins using hierarchical partial-least-squares regression to latent structures (Hi-PLS). Models were based on information from the 2002 release of the PDBbind database containing (after in-house refinement) high-resolution X-ray crystallography and binding affinity (Kd or Ki) data for 612(More)
This paper presents an empirical quality assessment of use cases with the purpose to provide defect data from industry. In the assessment, twelve criteria, based on earlier research, were applied to 43 use cases from Volvo Car Corporation developed according to current practice. The collected defect data were statistically analyzed to determine significant(More)
Severe human malaria is attributable to an excessive sequestration of Plasmodium falciparum-infected and uninfected erythrocytes in vital organs. Strains of P. falciparum that form rosettes and employ heparan sulfate as a host receptor are associated with development of severe forms of malaria. Heparin, which is similar to heparan sulfate in that it is(More)
GOLDsurfer is a java-based analysis and graphics program for three-dimensional plotting of linkage disequilibrium (LD). Simultaneous presentation of LD measures, including recombination rate estimates and disease association statistics, helps to clarify LD patterns and facilitates interpretations based on multiple indices of local genetic data.
Proper information visualization has always been viewed as an important tool for research. Traditionally, however, it was regarded as only a tool, with information content and visualization analogous to an object and its representation, respectively. These days, visualization is increasingly seen as an integral part of information content , without which(More)