Fredrik Jonsson

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The Bayesian approach has been suggested as a suitable method in the context of mechanistic pharmacokinetic-pharmacodynamic (PK-PD) modeling, as it allows for efficient use of both data and prior knowledge regarding the drug or disease state. However, to this day, published examples of its application to real PK-PD problems have been scarce. We present an(More)
We report on the first demonstration of a quaternary-logical resonatorless optical memory element with information encoded in the structural phase of a single 80 nm gallium nanoparticle. The size of the memory element is comparable with bits in next-generation hard disks, and radically smaller than previously suggested memories exploiting optical(More)
Hornets, the largest social wasps, have a reputation of being facultatively nocturnal. Here we confirm flight activity of hornet workers in dim twilight. We studied the eyes and ocelli of European hornets (Vespa crabro) and common wasps (Vespula vulgaris) with the goal to find the optical and anatomical adaptations that enable them to fly in dim light.(More)
Clinical assessment scales, where subitem ratings are added and summarized as a total score, are convenient tools for monitoring disease progression and often used to measure the effect of drug treatment in clinical trials. Statistical evaluation of any beneficial treatment effects tends to focus on single-valued summary measures, for example, the(More)
This thesis is based on the publications listed below, referred to in the text by their Roman numerals. The papers are reprinted with the kind permission of the publishers of the journals. Assessing the reliability of PBPK models using data from methyl chloride-exposed, non-conjugating human subjects. Physiologically based pharmacokinetic modeling of(More)
In common households today the awareness of the electricity, water and waste consumption are rather low. This generates a behavior that conflicts with the existing goals of sustainable living. Together with Stockholm City and other companies The Interactive Institute is working with a project called Stockholm Royal Seaport, where the goal is to implement a(More)
Let an integer n ≥ 2 and a vector of independent, identically distributed random variables X = (X1,. .. , Xn) be given with P(X = 0) = 0 and define the self-normalized sum Zn = (P n i=1 Xi)/(P n i=1 X 2 i) 1/2. We derive a formula for EZ 2 n which enables us to prove that EZ 2 n ≥ 1 and that EZ 2 n = 1 if and only if the summands are symmetrically(More)
The Almost sure central limit theorem states in its simplest form that a sequence of independent, identically distributed random variables {X k } k≥1 , with moments EX 1 = 0 and EX 2 1 = 1, obeys lim n→∞ 1 log n n k=1 1 k I S k √ k ≤ x a.s. = Φ(x), for each value x. I{·} here denotes the indicator function of events, Φ the distribution function of the(More)