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  • Fredrik Ekström, Yuan-Ping Pang, Malin Boman, Elisabet Artursson, Christine Akfur, Susanne Börjegren
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 2006 (First Publication: 1 August 2006)
  • Inhibition of acetylcholinesterase (AChE) by organophosphorus compounds (OPs) such as pesticides and nerve agents causes acute toxicity or death of the intoxicated individual. The inhibited AChE mayContinue Reading
  • Fredrik Ekström, Andreas Hörnberg, Elisabet Artursson, Lars-Gunnar Hammarström, Gunter Schneider, Yuan-Ping Pang
  • Chemistry, Medicine
  • PloS one
  • 2009 (First Publication: 18 June 2009)
  • Organophosphonates such as isopropyl metylphosphonofluoridate (sarin) are extremely toxic as they phosphonylate the catalytic serine residue of acetylcholinesterase (AChE), an enzyme essential toContinue Reading
  • Anders Allgardsson, Lotta Berg, +4 authors Fredrik Ekström
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 2016 (First Publication: 17 May 2016)
  • Organophosphorus nerve agents interfere with cholinergic signaling by covalently binding to the active site of the enzyme acetylcholinesterase (AChE). This inhibition causes an accumulation of theContinue Reading
  • Fredrik Ekström, Crister Åstot, Y-P Pang
  • Medicine, Chemistry
  • Clinical pharmacology and therapeutics
  • 2007 (First Publication: 1 September 2007)
  • Organophosphorus compound-based nerve agents inhibit the essential enzyme acetylcholinesterase (AChE) causing acute toxicity and death. Clinical treatment of nerve-agent poisoning is to useContinue Reading
  • Andreas Hörnberg, Anna-Karin Tunemalm, Fredrik Ekström
  • Chemistry, Medicine
  • Biochemistry
  • 2007 (First Publication: 1 April 2007)
  • Organophosphorus compounds (OPs), such as nerve agents and a group of insecticides, irreversibly inhibit the enzyme acetylcholinesterase (AChE) by a rapid phosphorylation of the catalytic Ser203Continue Reading