Frederico Martins

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BACKGROUND The extraction method of bioactive compounds is an important step in the manufacturing of herbal medicines, because secondary metabolites with therapeutic potential are usually found in small quantities in plant materials. OBJECTIVE Due the potential of Apeiba tibourbou Aubl, this study aimed to evaluate the impact of the extraction method on(More)
Ultraviolet B (UVB) irradiation may cause oxidative stress- and inflammation-dependent skin cancer and premature aging. Pyrrolidine dithiocarbamate (PDTC) is an antioxidant and inhibits nuclear factor-κB (NF-κB) activation. In the present study, the mechanisms of PDTC were investigated in cell free oxidant/antioxidant assays, in vivo UVB irradiation in(More)
ETHNOPHARMACOLOGICAL RELEVANCE Synadenium umbellatum Pax. is widely found in South America and empirically used in Brazil for the treatment of several diseases, mainly cancer. The aim of the study was to investigate cell death mechanisms induced by Synadenium umbellatum Pax. using Ehrlich ascites tumor (EAT) cells, as well as the myelotoxicity potential of(More)
In this article we present a smart textile system for the continuous monitoring of cardiorespiratory signals, produced and integrated with an industrial embroidery unit. The design of a T-shirt system, having embedded textile sensors and interconnects and custom designed circuit for data collection and Bluetooth transmission is presented. The performance of(More)
Wearable systems are expected to contribute for improving traditional biopotential signals monitoring devices due to higher freedom and unobtrusiveness provided to the wearer. Textile electrodes present advantages compared with the conventional Ag/AgCl electrodes for the capturing of biopotentials, namely in terms of skin irritation due to the hydrogel and(More)
BACKGROUND The standardized liquid extract of Brosimum gaudichaudii Trécul is an alternative for the treatment of vitiligo. There is a shortage of solid oral dosage forms developed from standardized extracts of this plant specie. OBJECTIVE This study is aimed to obtain pellets with a standardized liquid extract of B. gaudichaudii. RESULTS The(More)
BACKGROUND Calendula officinalis L. (Asteraceae) is a Mediterranean specie, but in Europe and America it is cultivated for ornamental or medicinal purposes. This species is widely used for presenting activities, antiinflammatory antibacterial and antioxidant. However the therapeutic action is linked to the amount of assets of the extracted raw material. The(More)
BACKGROUND Myrcia amazonica. DC is a species predominantly found in northern Brazil, and belongs to the Myrtaceae family, which possess various species used in folk medicine to treat gastrointestinal disorders, infectious diseases, and hemorrhagic conditions and are known for their essential oil contents. MATERIALS AND METHODS This study aimed applied the(More)
INSTRUCTION Despite the increased use of Brosimum gaudichaudii roots as raw material on medicine to treatment of vitiligo, there are not studies that showing the impact of unit operations on the quality and standardized of the extract of B. gaudichaudii. The quality of the herbal extract is essential to ensure the safety and efficacy of pharmaceutical(More)
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