Frederico F. Campos

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Antidepressants have been considered by their analgesic activity in numerous studies, and specifically tricyclic antidepressants to possess the greatest efficacy. Imipramine and doxepin have been reported to exhibit local anaesthetic properties. In order to investigate their cutaneous analgesic effect after topical application a nanoemulsion vehicle was(More)
MOTIVATION Receptor-ligand interactions are a central phenomenon in most biological systems. They are characterized by molecular recognition, a complex process mainly driven by physicochemical and structural properties of both receptor and ligand. Understanding and predicting these interactions are major steps towards protein ligand prediction, target(More)
The exponents method for calculating the concentrations of species in multimetal-multiligand systems is introduced. This method uses the NewtonRaphson method with restricted step iteration, which guarantees a monotonically decreasing objective function. Variable transformation and scaling are performed to avoid underflows and overflows during the(More)
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