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CONTEXT The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear. OBJECTIVE The objective of the study was to investigate the relationships between lifestyle and health with reproductive hormones in aging men. DESIGN This was a baseline cross-sectional survey on 3200 community-dwelling men aged 40-79 yr(More)
Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by X-ray (DXA), may be convenient alternatives for evaluating osteoporosis and fracture risk. We performed a meta-analysis of genome-wide association (GWA) studies to assess the genetic determinants of heel(More)
CONTEXT Physical frailty is associated with reduced muscle strength, impaired physical function, and quality of life. Testosterone (T) increases muscle mass and strength in hypogonadal patients. It is unclear whether T has similar effects in intermediate-frail and frail elderly men with low to borderline-low T. OBJECTIVE Our objective was to determine the(More)
CONTEXT Reference ranges are essential for partitioning testosterone levels into low or normal and making the diagnosis of androgen deficiency. We established reference ranges for total testosterone (TT) and free testosterone (FT) in a community-based sample of men. METHODS TT was measured using liquid chromatography tandem mass spectrometry in nonobese(More)
OBJECTIVE To assess the influence of sex hormones on markers of bone turnover and to explore the association between these markers and bone health in middle-aged and elderly European men. DESIGN A cross-sectional population-based survey. METHODS Men aged 40-79 years were recruited from population registers in eight European centres. Subjects completed a(More)
BACKGROUND Few published data link overweight and obesity with measures of quality of life (QoL) including sexual health in men. OBJECTIVE To assess the association of overweight/obesity with impairment of physical and psychological QoL and sexual functions in men. DESIGN AND SETTING Cross-sectional, multicentre survey of 3369 community-dwelling men(More)
INTRODUCTION Limited information is available concerning the general and sexual health status of European men. AIM To investigate the age-related changes in general and sexual health in middle-aged and older men from different countries of the European Union. METHODS This is a cross-sectional multicenter survey performed on a sample of 3,369(More)
OBJECTIVES The effect of testosterone (T) on sexual function in men is well established. However, less is known about its effects on cognitive function. The aim of this study is to investigate the relationship between T levels and sex-typed cognitive abilities in both eugonadal and hypogonadal men. DESIGN A single-blind placebo-controlled design was(More)
CONTEXT Polymorphisms in genes involved in regulation, biosynthesis, metabolism, and actions of testicular sex hormones may influence hormone balance and phenotype of aging men. OBJECTIVE We investigated the relationships between polymorphisms in genes related to pituitary-testicular endocrine function and health status. DESIGN AND SETTING Using(More)
The effects of a synthetic oral progestogen, desogestrel (DSG), administered with low dose testosterone (T) were investigated to determine the optimal combination for suppression of gonadotropins and spermatogenesis to targets compatible with effective male contraception. Twenty-four healthy male volunteers (33.2 +/- 0.9 yr) were randomly assigned to 3(More)