Frederick Web Fraunfelder

Learn More
OBJECTIVE Population-based studies of patients with ankylosing spondylitis indicate that tumor necrosis factor (TNF) inhibitors prevent uveitis. Paradoxically, anecdotal reports implicate etanercept as a cause of uveitis. Therefore, using the information from 2 drug events databases, the purpose of this study was to assess reported cases of uveitis(More)
PURPOSE To evaluate reported ocular side effects associated with isotretinoin usage. METHODS One thousand seven hundred forty-one case reports received from spontaneous reporting systems, data from the Drug Safety Section of Roche Pharmaceuticals, and the world's literature were evaluated using the World Health Organization Causality Assessment Guide of(More)
PURPOSE To report the association between 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) and diplopia, blepharoptosis (ptosis), and ophthalmoplegia. DESIGN Database study. PARTICIPANTS Two hundred fifty-six subjects studied. METHODS Spontaneous reports from the National Registry of Drug-Induced Ocular Side Effects, the World(More)
PURPOSE To evaluate spontaneous reports of ocular side effects associated with topiramate use. DESIGN Retrospective case series. METHODS One hundred fifteen case reports, primarily of a specific ocular syndrome (acute secondary angle-closure glaucoma), were collected from spontaneous reporting systems: the Drug Safety section of Ortho-McNeil(More)
This retrospective case series describes ocular side-effects associated with imatinib mesylate (Gleevec) and the clinical characteristics of these adverse reactions. A chart review of 104 patients on imatinib mesylate therapy from Oregon Health & Science University's Cancer Center were studied with regard to ocular side-effects. In addition, spontaneous(More)
This article reviews several retrospective case series and reported adverse events regarding common ocular adverse effects related to systemic therapy. It is not intended as a comprehensive summary of these well described adverse drug reactions, nor is it intended to cover the complete spectrum of all ocular adverse effects of systemic therapy. Many(More)
PURPOSE To compare postoperative outcomes for femtosecond laser-assisted keratoplasty (FLAK) with conventional penetrating keratoplasty (PK). DESIGN Retrospective, comparative surgical series. PARTICIPANTS Fifty consecutive patients who underwent FLAK and 50 case-controlled patients that had PK at the Casey Eye Institute (Oregon Health & Science(More)
PURPOSE To review the more significant herbal and nutritional agents of clinical importance to ophthalmologists and describe the ocular side effects for each. World Health Organization (WHO) classification and guidelines for clinicians are provided. DESIGN Retrospective observational case series. METHODS A retrospective observational case series of(More)
CONTEXT Retrospective case series, database study and literature review. Forty case reports are described. OBJECTIVE To report a possible association between fluoroquinolones and uveitis. MATERIALS AND METHODS Spontaneous reports from the National Registry of Drug-Induced Ocular Side effects, World Health Organization, and Food and Drug Administration(More)