Frederick S. Vizeacoumar

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We present a certain programming paradigm for implementing low-footprint applications on small embedded platforms and a tiny operating system based on that paradigm. The primary objective of our work was to create a friendly environment for rapid, reliable, and efficient deployment of customizable microcontroller applications primarily (but not necessarily)(More)
The dimorphic switch from a single-cell budding yeast to a filamentous form enables Saccharomyces cerevisiae to forage for nutrients and the opportunistic pathogen Candida albicans to invade human tissues and evade the immune system. We constructed a genome-wide set of targeted deletion alleles and introduced them into a filamentous S. cerevisiae strain,(More)
Improved efforts are necessary to define the functional product of cancer mutations currently being revealed through large-scale sequencing efforts. Using genome-scale pooled shRNA screening technology, we mapped negative genetic interactions across a set of isogenic cancer cell lines and confirmed hundreds of these interactions in orthogonal co-culture(More)
About one-fifth of the genes in the budding yeast are essential for haploid viability and cannot be functionally assessed using standard genetic approaches such as gene deletion. To facilitate genetic analysis of essential genes, we and others have assembled collections of yeast strains expressing temperature-sensitive (ts) alleles of essential genes. To(More)
Triple-negative breast cancer (TNBC) represents an aggressive subtype, for which radiation and chemotherapy are the only options. Here we describe the identification of disulfiram, an FDA-approved drug used to treat alcoholism, as well as the related compound thiram, as the most potent growth inhibitors following high-throughput screens of 3185 compounds(More)
Triple negative breast cancer (TNBC) includes basal-like and claudin-low subtypes for which only chemotherapy and radiation therapy are currently available. The retinoblastoma (RB1) tumor suppressor is frequently lost in human TNBC. Knockdown of RB1 in luminal BC cells was shown to affect response to endocrine, radiation and several antineoplastic drugs.(More)
CREB3L1 (cAMP-responsive element-binding protein 3-like protein 1), a member of the unfolded protein response, has recently been identified as a metastasis suppressor in both breast and bladder cancer. Quantitative real time PCR (qPCR) and immunoblotting were used to determine the impact of histone deacetylation and DNA methylation inhibitors on CREB3L1(More)
In wireless environment, the routing process is becoming more complicated as they cause delays in the process of transmission of data. In order to over come this process, many ideas have been proposed to overcome this problem. In this project we would like to monitor the idea of routing the data, using node disjoint paths algorithm to decrease the delay(More)
Many previous studies provides evidence that Quality of Service (QoS) routing can provides a better network utilization compared to the routing, which is not involving a QoS measure. Various researches have been made in this area and several algorithms and scheduling process have been introduced. Later, it was found that when the path from a specific source(More)
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