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For nearly 50 years, nerve agents have constituted a serious threat that has stimulated extensive efforts to develop effective medical countermeasures. Recent progress in producing pharmacologic… (More)
Although sulfur mustard (SM) has been used as a chemical warfare agent since the early twentieth century, it has reemerged in the past decade as a major threat around the world. SM is an agent that… (More)
Nerve agents are highly potent and rapidly acting organophosphorus compounds that irreversibly bind and inactive acetylcholinesterase. Only rarely have they been used in warfare, but their great… (More)
SUMMARY Chemicals have been used as military weaponsfor more than 2,000 years. From the flame andsmoke of ancient Greece to the nerve agents andvesicants of the Iran-Iraq war, theses weapons… (More)
A case of accidental human exposure to sulfur mustard, the chemical warfare agent, was documented. The exposure produced skin damage in the form of erythema and blisters comprising less than 5% of… (More)
Nerve agents, highly toxic organophosphorus cholinesterase inhibitors, inhibit acetylcholinesterase and cause an accumulation of acetylcholine. Clinical effects depend on the route and amount of… (More)