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BACKGROUND Cells respond to environmental stressors through several key pathways, including response to reactive oxygen species (ROS), nutrient and ATP sensing, DNA damage response (DDR), and epigenetic alterations. Mitochondria play a central role in these pathways not only through energetics and ATP production but also through metabolites generated in the… (More)
I n January of 2002, a call for papers featuring community based participatory research (CBPR) was issued. The intent was to highlight the outstanding work being done in this area and the role CBPR can play in improving the care and outcomes of populations at-risk. 1 What emerged from this call was more than what any of the editors expected, and has been… (More)
In the last ten years, traditional population-based biomedical research methods have been challenged due to limited community participation. Proponents for change explain that community participation, as an active partner in the research process, provides numerous benefits to research findings and public health intervention outcomes. In addition, community… (More)
oceans have been perceived by mankind as a producer of essential protein, a vital transportation artery, a source of great danger (from storms, hurricanes, typhoons, tsunamis, and venomous and predatory animals) and the greatest mystery on the planet, inspiring untold realms of poetry and prose. The oceans are the world's most important sources of… (More)
a r t i c l e i n f o Epigenetic dysregulation in disease is increasingly studied as a potential mediator of pathophysiology. The epigenetic events are believed to occur in somatic cells, but the limited changes of DNA methylation in studies to date indicate that only subsets of the cells tested undergo epigenetic dysregulation. The recognition of this… (More)
Background: Nidogens are highly conserved proteins of basement membranes. Two nidogen proteins, nidogen 1 and nidogen 2, are known in mammals.
Environmental justice (EJ) refers to the need to remedy the disproportionate residential and occupational exposures borne by socioeconomically disadvantaged populations. The main objective of the EJ program is to establish methods for linking members of a community who are directly affected by adverse environmental conditions with researchers and health… (More)