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Evidence implicates subtle neuronal pathology of the prefrontal cortex (PFC) in schizophrenia, but how this pathology is reflected in physiological neuroimaging experiments remains controversial. We investigated PFC function in schizophrenia using functional magnetic resonance imaging (fMRI) and a parametric version of the n-back working memory (WM) task.(More)
BACKGROUND Shared neurobiological characteristics of patients with schizophrenia and their siblings may represent "intermediate phenotypes" that may more closely reflect the genetic susceptibility underlying this illness. We sought evidence of such phenotypes using magnetic resonance spectroscopy based on previously described regional abnormalities in(More)
OBJECTIVE Certain cognitive, behavioral, and emotional deficits (so-called negative symptoms) in patients with schizophrenia have often been attributed to prefrontal cortical pathology, but direct evidence for a relationship between prefrontal neuronal pathology and negative symptoms has been lacking. The authors hypothesized that an in vivo measure of(More)
CONTEXT Schizophrenia is a devastating illness with an indeterminate pathophysiology. Several lines of evidence implicate dysfunction in the thalamus, a key node in the distributed neural networks underlying perception, emotion, and cognition. Existing evidence of aberrant thalamic function is based on indirect measures of thalamic activity, but dysfunction(More)
Sleep is a behavioral state ideal for studying functional connectivity because it minimizes many sources of between-subject variability that confound waking analyses. This is particularly important for potential connectivity studies in mental illness where cognitive ability, internal milieu and active psychotic symptoms can vary widely across subjects. We,(More)
In order to evaluate the possibility of an intensive radiotherapy of lung cancer in patients 70 years or older we compared the treatment results of 375 such patients with those, which we achieved in younger patients with the same kind of treatment. In non-small cell lung cancer radiation treatment with curative intent yielded at least equally good results(More)
BACKGROUND Emergency department (ED) delays have multiple causes and create frustration for patients and staff alike. METHODS New adult psychiatric ED consultations were studied. Elapsed time between workflow stages was tested as a predictor of total time from triage to disposition. To expedite interviews a one-page form was provided for interested(More)
172 patients with limited disease of non-small cell carcinoma of the lung were irradiated with curative intent. Complete remission and partial remission were achieved in 44%, and 39% respectively. The median survival time was 390 days in the whole group and 560 days in patients with stage T1,2N0M0. The 3-year survival rate was 14% in the whole group and 25%(More)
The main problems of radiotherapy planning are discussed with respect to use of computers now being available for a greater number of centers. One of the most essential premises is apart from clear ideas on a modern target volume concept - a sufficiently high speed in producing realistic summarized isodose contours for any radiation therapy arrangement in(More)