Frederick F. Marciano

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STUDY DESIGN Retrospective review of acute axis fractures treated at a tertiary referral center. OBJECTIVE To determine the optimal treatment of axis fractures based on 340 cases from a single institution. SUMMARY OF BACKGROUND DATA Axis fractures account for almost 20% of acute cervical spine fractures. However, their management and the clinical(More)
OBJECTIVE This prospective, randomized, controlled study was designed to investigate the safety, feasibility, and preliminary efficacy of long-term CSF drainage via a low-flow ventriculoperitoneal shunt in subjects suffering from AD. METHODS Twenty-nine subjects selected for probable AD (National Institute of Neurological and Communicative Diseases and(More)
OBJECTIVE Lesions situated posterolaterally along the mesencephalon present neurosurgeons with a special challenge. The midline and paramedian variations of the supracerebellar infratentorial approaches do not adequately expose this region. The subtemporal approach risks injury to the vein of Labbé. An extreme lateral supracerebellar infratentorial approach(More)
The drug, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP), depletes striatal dopamine levels in primates and certain rodents, including mice, and produces parkinsonian-like symptoms in humans and nonhuman primates. To investigate the consequences of grafting adrenal medullary tissue into the brain of a rodent model of Parkinson's disease, a piece of(More)
OBJECTIVE A standard top-loading lumbar pedicle screw-rod system is compared with a pedicle screw-plate system with smaller-diameter screws, more medial entry, and lower profile to assess the relative stability, strength, and resistance to fatigue of the 2 systems. METHODS Seven human cadaveric specimens were studied with each surgical construct.(More)
The presence of traumatic subarachnoid hemorrhage (tSAH) on admission computerized tomography (CT) scans obtained from patients suffering from severe, nonpenetrating head injury has been shown to be associated with a worse outcome than the injury alone would warrant. However, no previous study has provided a simple means of relating the amount of tSAH, its(More)
While the cholinergic projection from the nucleus basalis to the cortical mantle has received considerable attention, a similar projection to the magnocellular basal nucleus of the amygdala has not been studied in such detail. The present study analyzed the cholinergic basal forebrain projection to the amygdala in the Cebus apella monkey by using combined(More)
STUDY DESIGN A new anchored spacer-a low-profile cervical interbody fusion cage with integrated anterior fixation-was compared biomechanically to established anterior cervical devices. OBJECTIVE To evaluate the fixation properties of the new stand-alone device and compare these properties with established fixation methods. The hypothesis is that the new(More)
BACKGROUND CONTEXT Most one-level anterior cervical plates use two screws per vertebra (four screws in total). No study has addressed whether a simplified plate using one screw per vertebra is adequate for one-level fixation. PURPOSE To compare stability achieved by four-screw and two-screw plates after discectomy and placement of interbody spacer. (More)
Regeneration and functional recovery of the hypothalamoneurohypophysial system (HNS) in neurohypophysectomized rats treated with either saline or vasopressin (VP) were analyzed utilizing specific immunohistochemical and physiological measures. Neural lobe ablation combined with VP administration precipitated a profound diabetes insipidus (following(More)