Frederick B J M Thunnissen

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The purpose of this study is to evaluate the prognostic value of the combined assessment of multiple molecular markers related to the epidermal growth factor receptor (EGFR) pathway in resected non-small cell lung cancer (NSCLC) patients. Tumour specimens of 178 NSCLC patients were collected and analysed for EGFR and KRAS mutation status by DNA sequencing,(More)
PURPOSE Kirsten ras (K-ras) point mutations are found in 30% to 56% of pulmonary adenocarcinomas by means of highly sensitive techniques. Recently, the Point-EXACCT (point mutation detection using exonuclease amplification coupled capture technique) method was described, which detected one cell with a mutation in 15,000 normal cells. The aim of this study(More)
SirdWe read with interest the manuscript by Chowdhury et al.1 reporting the occurrence of sarcoid-like reactions in 1.1% of cancer patients at 2[18F]-fluoro-2-deoxy-D-glucose (FDG)/computed tomography (CT) examination. We also observed FDG uptake in sarcoid-like reactions in cancer patients. In addition, we have observed two cancer patients with mediastinal(More)
BACKGROUND In this study, the potential impact of a new national guideline for adjuvant systemic therapy in breast cancer (introduced in The Netherlands in 1998) was assessed, as well as the modifications of this guideline, issued in 2001. Both the change in total number of patients eligible for adjuvant therapy, as well as the cost-effectiveness of the(More)
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