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- Catherine S Manno, Amy J Chew, +17 authors Bertil Glader
- Blood
- 2003

Hemophilia B is an X-linked coagulopathy caused by absence of functional coagulation factor IX (F.IX). Previously, we established an experimental basis for gene transfer as a method of treating the disease in mice and hemophilic dogs through intramuscular injection of a recombinant adeno-associated viral (rAAV) vector expressing F.IX. In this study we… (More)

- S D Lewis, F A Johnson, J A Shafer
- Biochemistry
- 1981

Papain was succinylated in order to increase its solubility above pH 8 so that proton NMR spectroscopy could be used to study the ionization of His-159 at the active site of the enzyme. The pH dependence of NMR spectra of catalytically active succinyl-papain and the methylthio derivative of the active-site cysteinyl residue of succinyl-papain… (More)

- F A Johnson, S D Lewis, J A Shafer
- Biochemistry
- 1981

Fluorometric titrations of papain, succinyl-papain, and the corresponding methylthio derivatives of Cys-25 (papain-S-SCH3 and succinyl-papain-S-SCH3) were determined. Removal of the methylthio group from Cys-25 resulted in an increase of approximately 4 pK units in the fluorometrically determined pK value. The correspondence between the ionization behavior… (More)

- Frederick A. Johnson
- Notre Dame Journal of Formal Logic
- 1989

A semantics is presented for Storrs McCalΓs separate axiomatizations of Aristotle's accepted and rejected polysyllogisms. The polysyllogisms under discussion are made up of either assertoric or apodeictic propositions. The semantics is given by associating a property with a pair of sets: one set consists of things having the property essentially and the… (More)

- F A Johnson, D Q Craig, A D Mercer
- The Journal of pharmacy and pharmacology
- 1997

Sodium alginates are widely used within the pharmaceutical sciences, yet the molecular characteristics of these materials are frequently not stated. In this study, a range of characterization techniques is applied to five sodium alginate samples and the data compared, both between techniques and with the information obtained from the manufacturer. The… (More)

- S D Lewis, F A Johnson, J A Shafer
- Biochemistry
- 1976

The ionization behavior of groups at the active site of papain was determined from the pH dependence of the difference of proton content of papain and the methylthio derivative of the thiol group at the active site of papain (papain-S-SCH3). This difference in proton content was determined directly by two independent methods. One method involved… (More)

Regular neighborhoods have proved to be a very useful tool in the theory of PL manifolds. In this paper we want to make a very easy construction of regular neighborhoods in the topological category. F. E. A. Johnson [6] has constructs regular neighborhoods in the topological category, but only in the case of nonintersection with the boundary. R. D. Edwards… (More)

- Frederick A. Johnson
- Notre Dame Journal of Formal Logic
- 1999

A theorem due to Shoesmith and Smiley that axiomatizes twovalued multiple-conclusion logics is extended to partial logics. Rumfitt [1] extends Smiley’s [3] discussion of rejection by axiomatizing a calculus where truth values of sentences are given by truth tables that admit truth-value gaps. “The Smiley multiple-conclusion consequence relation” for the… (More)

- F. E. A. JOHNSON
- 2010

We construct examples of locally symmetric spaces which fibre, with both base space and fibre also locally symmetric, in two distinct ways so that neither fibre nor base of one is homeomorphic to either fibre or base of the other. The simplest example is a complex surface which fibres over a complex curve in two essentially distinct ways. In consequence,… (More)

- F A Johnson, S D Lewis, J A Shafer
- Biochemistry
- 1981

Proton NMR spectroscopy was used to study the ionization behavior of His-159 in a derivative of papain (papain-S-SCH3). In this catalytically inactive derivative of papain, the active-site thiol group of Cys-25 is S-methyl-thiolated so that it cannot form a thiolate anion. The pH dependence of the chemical shift of the C epsilon 1 H resonance of His-159… (More)