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Hemophilia B is an X-linked coagulopathy caused by absence of functional coagulation factor IX (F.IX). Previously, we established an experimental basis for gene transfer as a method of treating the disease in mice and hemophilic dogs through intramuscular injection of a recombinant adeno-associated viral (rAAV) vector expressing F.IX. In this study we(More)
A semantics is presented for Storrs McCalΓs separate axiomatiza-tions of Aristotle's accepted and rejected polysyllogisms. The polysyllogisms under discussion are made up of either assertoric or apodeictic propositions. The semantics is given by associating a property with a pair of sets: one set consists of things having the property essentially and the(More)
The development of central projections of sensory neurons in lumbosacral dorsal root ganglia (DRGs) was examined by using horseradish peroxidase labeling techniques in chick embryos from stage 23 (E4) to stage 39 (E13). Our results show that primary afferents reach the spinal cord by stage 23. Afferent axons extend in the primordium of the dorsal funiculus(More)
Imaging of regenerating optic fibers in living adult goldfish was used to visualize arbor restructuring during activity-dependent refinement. A small number of neighboring retinal ganglion cells were labeled with DiI and observed in the tectum of the living animal for 5-7 hours during the period of activity-dependent refinement. In contrast to earlier(More)
A theorem due to Shoesmith and Smiley that axiomatizes two-valued multiple-conclusion logics is extended to partial logics. Rumfitt [1] extends Smiley's [3] discussion of rejection by axiomatizing a calculus where truth values of sentences are given by truth tables that admit truth-value gaps. " The Smiley multiple-conclusion consequence relation " for the(More)
For any finite group G the group U (Z[G]) of units in the integral group ring Z[G] is an arithmetic group in a reductive algebraic group, namely the Zariski closure of SL 1 (Q[G]). In particular, the isomorphism type of the Q-algebra Q[G] determines the commensurability class of U (Z[G]); we show that, to a large extent, the converse is true. In fact,(More)