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  • Yasuchika Yamaguchi, Keith Allan Menear, +5 authors Juergen Klaus Maibaum
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 1 August 2009
  • Novel nonpeptide small molecule renin inhibitors bearing an N-isopropyl P(1) motif were designed based on initial lead structures 1 and aliskiren (2). (P(3)-P(1))-Benzamide derivatives such as 9a andContinue Reading
  • Frederic Cumin, V Vellaud, Pierre Corvol, François Alhenc-Gelas
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 1 September 1989
  • Binding of the potent radiolabelled competitive inhibitor 3H RU 44403 to pure human kidney angiotensin-I converting enzyme was examined in equilibrium and non equilibrium conditions. EquilibriumContinue Reading