Frederic Brandt

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Interleukin-1 (IL-1) has been implicated in the mechanism of human parturition in the setting of infection. The purpose of this study was to determine the effect of labor (term and preterm) and microbial invasion of the amniotic cavity on amniotic fluid (AF) concentrations IL-1 alpha and IL-1 beta. AF was retrieved by transabdominal amniocentesis from the(More)
OBJECTIVE The purpose of this study was to determine the prevalence and clinical significance of microbial invasion of the amniotic cavity in patients presenting with cervical dilatation in the midtrimester of pregnancy. STUDY DESIGN Amniocentesis for microbial studies was performed in women admitted with cervical dilatation > or = 2 cm, intact membranes,(More)
OBJECT Parkinson's disease (PD) is a prevalent neurodegenerative disorder that becomes refractory to medication as the disease progresses. Although in the past 5 years increasing numbers of patients have undergone stereotactically guided posteroventral pallidotomy for advanced PD, the safety and efficacy of surgery remains to be documented. The goal in this(More)
The article describes the pathophysiological mechanisms of injuries caused by shots in the head. In particular, the effect exercised on the cerebral tissue by the impact of rapid projectiles is explained. The review is based on 23 patients treated by the authors. These cases are discussed and critically assessed, using the results communicated in other(More)
OBJECTIVE Interleukin-1 has been implicated in the mechanisms responsible for preterm labor in the setting of infection. The interleukin-1 receptor antagonist is a new member of the interleukin-1 gene family that inhibits the biologic effects of interleukin-1 by blocking its receptors. Reduction of interleukin-1-induced prostaglandin production by(More)
Chondrodysplasia punctata has been classified into two major types including the rare autosomal recessive "rhizomelic type" and a more common but genetically heterogenous nonrhizomelic type (referred to by some authors as "Conradi-Hünermann (CH) type"). The former is typically lethal, manifesting serious anomalies, and allowing several instances of(More)
Primary pulmonary sporotrichosis is a rare disease. Comstock and Wolson (1975) were able to trace approximately 30 such cases. We report a further case; to our knowledge, the various stages in the development of sporotrichosis, from a cigar body to the mature asteroid body with radiations which were present in our case, have not been so well demonstrated in(More)