The predictive value of KRAS mutation in metastatic colorectal cancer (MCRC) patients treated with cetuximab plus chemotherapy has recently been suggested. In our study, 59 patients with a chemotherapy-refractory MCRC treated with cetuximab plus chemotherapy were included and clinical response was evaluated according to response evaluation criteria in solid… (More)
Recent studies have suggested that activation of the EGFR pathway leads to malignant transformation only if the p53 protein is inactivated. Therefore, we evaluated the impact of TP53 mutations on cetuximab-based chemotherapy (CT) sensitivity in combination with KRAS mutations that have been associated with cetuximab resistance. KRAS and TP53 status were… (More)
Circadian rhythms offer probably the best understanding of how genes control behavior, and much of this understanding has come from studies in Drosophila. More recently, genetic manipulation of clock neurons in Drosophila has helped identify how daily patterns of activity are programmed by different clock neuron groups. Here, we review some of the more… (More)
Musical dichotic listening by musicians and non-musicians free from nervous affections was investigated under different situations which provoke modification of activity of each cerebral hemisphere. The melodic stimuli produced a greater response in the left hemisphere in musicians and in the right hemisphere in the non-musicians.
iii ACKNOWLEDGEMENTS I would like to thank my committee members, Drs. for their invaluable advice and guidance over the past few years. Special thanks are due to my advisor, Terry Maple, who has always encouraged, inspired, and given me confidence in myself. I also owe a debt of gratitude to Bonnie Perdue, for helping in the data collection, for her… (More)