Fred de Sauvage
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Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons.
The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LpL) along the luminal surface of the capillaries. However, the endothelial cell molecule that facilitates chylomicron… Expand
The magnitude of hedgehog signaling activity defines skin tumor phenotype
Gain‐of‐function mutations in SMO have been implicated in constitutive activation of the hedgehog signaling pathway in human basal cell carcinomas (BCCs). We used a truncated keratin 5 (ΔK5) promoter… Expand
Decreased food intake does not completely account for adiposity reduction after ob protein infusion.
- N. Levin, C. Nelson, A. Gurney, R. Vandlen, F. de Sauvage
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 20 February 1996
The effects of recombinantly produced ob protein were compared to those of food restriction in normal lean and genetically obese mice. Ob protein infusion into ob/ob mice resulted in large decreases… Expand
The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity1
- D. Artis, A. Villarino, +15 authors C. Hunter
- Biology, Medicine
- The Journal of Immunology
- 1 November 2004
Although previous studies have investigated the role of IL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies… Expand
GFR alpha-4 and the tyrosine kinase Ret form a functional receptor complex for persephin.
Glial-cell-line-derived neurotrophic factor (GDNF), neurturin and persephin are structurally related, secreted proteins that are widely expressed in the nervous system and other tissues and promote… Expand
Effect of bevacizumab (BV) and chemotherapy (CT) on serum levels of vascular endothelial growth factor receptor-2 (sVEGFR-2) in patients with inflammatory and locally advanced breast cancer.
- J. Walshe, N. Denduluri, +7 authors S. Swain
- Journal of clinical oncology : official journal…
- 20 June 2006
13003 Background: VEGFR-2 is a principal mediator of angiogenesis. The effects on sVEGFR-2 after anti-angiogenesis therapy are unknown. METHODS Twenty-one patients (pts) with breast cancer… Expand