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The study of antibody-antigen interactions should greatly benefit from the development of quantitative models for the evaluation of binding free energies in proteins. The present work addresses this challenge by considering the test case of the binding free energies of phosphorylcholine analogs to the murine myeloma protein McPC603. This includes the(More)
In the past few years, wireless microsensor networks have attracted a great deal of attention in the research community. This is due to the applications that will be enabled once wireless microsensor networks are in place. The design of wireless microsensor networks, however, represents a difficult challenge. Since many applications require fault-tolerant,(More)
| Ultra-wide-band (UWB) communication has a variety of applications ranging from wireless USB to radiofrequency (RF) identification tags. For many of these applications, energy is critical due to the fact that the radios are situated on battery-operated or even batteryless devices. Two custom low-power impulse UWB systems are presented in this paper that(More)
Long distance, low data-rate UWB communication for sensor network applications requires a highly energy efficient transceiver combined with circuit and system-level optimizations to maximize range. A custom pulsed-UWB transceiver chipset in 90nm CMOS is presented that targets these aggressive specifications. The transceiver efficiently communicates at data(More)
This paper presents analysis of a digital Ultrawideband (UWB) radio receiver operating in the 3.1 GHz to 10.6 GHz band. Analog to digital converter (ADC) bit precision is analyzed on two types of UWB signals OFDM UWB and pulsed UWB all in the presence of Additive White Gaussian Noise (AWGN) and a narrowband interferer in the channel. This paper shows how(More)
The schuhli out is a device designed to lock an AO 4.5-mm cortical screw to a 4.5-mm dynamic compression plate independent of bony contact with the plate. The nut engages the screw below the plate, elevating the plate, and locking the screw at a 90 degrees angle, thus preventing toggling. Photoelastic modeling and biomechanical testing on sheep tibias were(More)
A custom UWB transceiver chipset is presented that communicates in three 550MHz-wide channels in the 3.1 to 5GHz band by using pulse position modulation (PPM). The transmitter uses an all-digital architecture and calibration technique to synthesize pulses with programmable width and center frequency. No analog bias currents or RF oscillators are required in(More)
MEMS-based oscillators offer a silicon-based alternative to quartz-based frequency references. Here, a MEMS-based programmable oscillator is presented which achieves better than 0.5-ppm frequency stability from 40 C to 85 C and less than 1-ps (rms) integrated phase noise (12 kHz to 20 MHz). A key component of this system is a thermistor-based(More)