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BACKGROUND The effects of constant-current deep brain stimulation (DBS) have not been studied in controlled trials in patients with Parkinson's disease. We aimed to assess the safety and efficacy of bilateral constant-current DBS of the subthalamic nucleus. METHODS This prospective, randomised, multicentre controlled trial was done between Sept 26, 2005,(More)
Although dysphagia is a common problem for many Parkinson's disease (PD) patients, the effect of deep brain stimulation (DBS) on swallowing is unclear. Fourteen subjects with advanced PD underwent videofluorographic swallowing studies prior to bilateral DBS of the subthalamic nucleus (STN) and at 3 and 12 months postprocedure. They were tested under several(More)
We investigated amnion-derived neurotrophic effects on embryonic day 14 rat mesencephalic (E14M) explants in co-culture. E14M explants showed extensive neurite outgrowth directed toward amnion tissue. Tyrosine hydroxylase immunocytochemistry, western immunoblot and [3H]dopamine uptake studies revealed significant neurotrophic effects on E14M dopaminergic(More)
A symptomatic lacunar infarct is an unusual complication which may develop during stereotactically guided pallidotomy using radiofrequency thermoablation. We describe a 54-year-old man with Parkinson's disease involving predominantly the right side, progressively deteriorating under medical management. He underwent stereotactically guided radiofrequency(More)
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