Fred Houben

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To determine the effects of fentanyl in newborn and premature infants, we compared two groups of 20 newborn and premature babies under artificial ventilation for severe respiratory distress syndrome: a prospective group receiving fentanyl for analgesic and sedation and a historical control group, who did not receive fentanyl. Fentanyl serum levels during(More)
Since 1975, the Department of Surgery in the Grevenbroich Community Hospital (Germany) has applied a simplified technique of open appendectomy. The inhouse modified procedure without stump embedding has been performed in 3,448 cases to date. The same approach has been used in 1,463 laparoscopic appendectomies since 1991. In the laparoscopic procedure the(More)
The complexity of today’s embedded systems and their development trajectories requires a systematic, model-driven design approach, supported by tooling wherever possible. Only then, development trajectories become manageable, with high-quality, cost-effective results. This paper introduces the Octopus Design-Space Exploration (DSE) toolset that aims to(More)
Scheduling concerns the allocation of resources to activities over time in order to achieve some goals. Scheduling problems occur in many different domains and a vast amount of research has been carried out in this area. However, in the research literature scheduling is usually seen as a function of known, perfect inputs: the set of jobs, their arrival(More)
Inspired by work on model-based design of printers, the notion of a parametrized partial order (PPO) has recently been introduced. PPOs are a simple extension of partial orders, expressive enough to compactly represent large task graphs with finite repetitive behavior. We present a translation of a subclass of PPOs to timed automata and prove that the(More)
Since 1975, the Department of Surgery in the Grevenbroich Community Hospital (Germany) has applied a simplified technique of open appendectomy. The inhouse modified procedure without stump embedding has been performed in 3,448 cases to date. The same approach has been used in 1,463 laparoscopic appendectomies since 1991. In the laparoscopic procedure the(More)
Modern high-tech embedded systems are constructed from a complex mix of hardware and software components. An important issue during the development of such complex embedded systems is getting to grips with the extremely large number of design options that are available. This is often referred to as the design space of a system under development. To support(More)
Since January 1981, the so-called “3-day principle” in cases of suspected appendicitis has been applied in order to render the indications for surgery more precise. The retrospective analysis of a total of 1877 appendectomies performed between 1981 and 1990 demonstrated that the majority of histologically definite cases of acute appendicitis had been(More)
In pediatric intensive care, analgesia and sedation has become increasingly important for newborns as well as prematures in recent years. However, its importance is frequently not well recognized and sedation is confounded with analgesia. In our intensive-care unit (ICU), fentanyl and midazolam have proved to be useful. In newborn and premature infants,(More)
Since January 1981, the so-called "3-day principle" in cases of suspected appendicitis has been applied in order to render the indications for surgery more precise. The retrospective analysis of a total of 1877 appendectomies performed between 1981 and 1990 demonstrated that the majority of histologically definite cases of acute appendicitis had been(More)
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