Fraser N Birrell

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OBJECTIVES Exercise is an effective and commonly prescribed intervention for lower limb osteoarthritis (OA). Many unanswered questions remain, however, concerning the practical delivery of exercise therapy. We have produced evidence-based recommendations to guide health-care practitioners. METHODS A multidisciplinary guideline development group was formed(More)
A 2-stage population screening survey of 2,000 inhabitants of 2 rural townships in southern Nigeria was undertaken. No case of rheumatoid arthritis (RA) was discovered in those responding, although 3 cases of inflammatory polyarthritis were found. One of these individuals satisfied the modification of the American College of Rheumatology classification tree(More)
British Society for Rheumatology and British Health Professionals in Rheumatology Guideline for the Management of Rheumatoid Arthritis (The first 2 years) R. Luqmani, S. Hennell, C. Estrach, F. Birrell, A. Bosworth, G. Davenport, C. Fokke, N. Goodson, P. Jeffreson, E. Lamb, R. Mohammed, S. Oliver, Z. Stableford, D. Walsh, C. Washbrook and F. Webb on behalf(More)
British Society for Rheumatology and British Health Professionals in Rheumatology Guideline for the Management of Rheumatoid Arthritis (the first two years) R. Luqmani, S. Hennell, C. Estrach, F. Birrell, A. Bosworth, G. Davenport, C. Fokke, N. Goodson, P. Jeffreson, E. Lamb, R. Mohammed, S. Oliver, Z. Stableford, D. Walsh, C. Washbrook and F. Webb on(More)
Raashid Luqmani, Sheena Hennell, Cristina Estrach, Damian Basher, Fraser Birrell, Ailsa Bosworth, Frank Burke, Carole Callaghan, Jaime Candal-Couto, Chris Fokke, Nicola Goodson, Dawn Homer, John Jackman, Paula Jeffreson, Susan Oliver, Mike Reed, Luis Sanz, Zoe Stableford, Peter Taylor, Nick Todd, Louise Warburton, Chris Washbrook and Mark Wilkinson, on(More)
OBJECTIVES To estimate the requirement for total hip replacement in the United Kingdom over the next three decades METHODS Projection of age and sex specific hip replacements in the UK over 10 year intervals taking account of demographic change and the extrapolation of arthroplasty rates from Sweden; a country with recently introduced guidelines. (More)
BACKGROUND Osteoarthritis is the most common form of arthritis worldwide and is a major cause of pain and disability in elderly people. The health economic burden of osteoarthritis is increasing commensurate with obesity prevalence and longevity. Osteoarthritis has a strong genetic component but the success of previous genetic studies has been restricted(More)
OBJECTIVE To investigate whether antidrug antibodies and/or drug non-trough levels predict the long-term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels to optimize future treatment decisions. METHODS A total of 331(More)
OBJECTIVE To quantify the direct and indirect effects of fetal (position in family, weight, and social class at birth), childhood (breast feeding, growth, infections, and social class in childhood, age at menarche), and adult life (social class, alcohol consumption, smoking, diet, reproductive history, exercise, hormone replacement therapy use), and adult(More)
OBJECTIVE Epidemiological data suggest low serum 25-hydroxyvitamin D3 (25-OH-D3) levels are associated with radiological progression of knee osteoarthritis (OA). This study aimed to assess whether vitamin D supplementation can slow the rate of progression. METHOD A 3-year, double-blind, randomised, placebo-controlled trial of 474 patients aged over 50(More)