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Function, regulation and pathological roles of the Gab/DOS docking proteins

• Franziska U. Wöhrle, Roger J. Daly, Tilman Brummer
• Cell Communication and Signaling
• 2009

Since their discovery a little more than a decade ago, the docking proteins of the Gab/DOS family have emerged as important signalling elements in metazoans. Gab/DOS proteins integrate and amplify… (More)

Gab2 signaling in chronic myeloid leukemia cells confers resistance to multiple Bcr-Abl inhibitors

• Franziska U. Wöhrle, Sebastian Halbach, +12 authors Tilman Brummer
• Leukemia
• 2013

Grb2-associated binder 2 (Gab2) serves as a critical amplifier in the signaling network of Bcr-Abl, the driver of chronic myeloid leukemia (CML). Despite the success of tyrosine kinase inhibitors… (More)

A novel MCF-10A line allowing conditional oncogene expression in 3D culture

• Ricarda Herr, Franziska U. Wöhrle, Christina Danke, Christian Berens, Tilman Brummer
• Cell Communication and Signaling
• 2011

Non-transformed mammary epithelial cell lines such as MCF-10A recapitulate epithelial morphogenesis in three-dimensional (3D) tissue culture by forming acinar structures. They represent an important… (More)

The immunohistochemical staining pattern of Gab2 correlates with distinct stages of chronic myeloid leukemia.

• Konrad Aumann, Silke Lassmann, +7 authors Tilman Brummer
• Human pathology
• 2011

Grb2-associated binder 2 protein (Gab2) is a member of scaffold proteins, playing crucial roles in (receptor-) tyrosine kinase and cytokine signaling. Chronic myeloid leukemia cells with… (More)

Alterations of Gab2 signalling complexes in imatinib and dasatinib treated chronic myeloid leukaemia cells

• Sebastian Halbach, Kristoffer T. G. Rigbolt, +4 authors Jörn Dengjel
• Cell Communication and Signaling
• 2012

The Gab2 docking protein acts as an important signal amplifier downstream of various growth factor receptors and Bcr-Abl, the driver of chronic myeloid leukaemia (CML). Despite the success of Bcr-Abl… (More)

How to Grb2 a Gab.

• Franziska U. Wöhrle, Roger J. Daly, Tilman Brummer
• Structure
• 2009

In this issue of Structure, Harkiolaki et al. use crystallography, peptide arrays and isothermal calorimetry to provide a detailed insight into the interaction between the C-terminal SH3 domain of… (More)

Axitinib and sorafenib are potent in tyrosine kinase inhibitor resistant chronic myeloid leukemia cells

• Sebastian Halbach, Zehan Hu, +4 authors Tilman Brummer
• Cell Communication and Signaling
• 2016

Chronic myeloid leukemia (CML) is driven by the fusion kinase Bcr-Abl. Bcr-Abl tyrosine kinase inhibitors (TKIs), such as imatinib mesylate (IM), revolutionized CML therapy. Nevertheless, about 20 %… (More)

The versatile role of Gab1 in the circulatory system.

• Franziska U. Wöhrle, Sebastian Halbach, Tilman Brummer
• Circulation journal : official journal of the…
• 2012

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