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The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus
Significance Terpenoids are the largest group of plant-specialized metabolites and include many valuable bioactive compounds, such as the blockbuster anticancer drugs vincristine and vinblastine,Expand
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Genome-guided investigation of plant natural product biosynthesis.
The medicinal plant Madagascar periwinkle, Catharanthus roseus (L.) G. Don, produces hundreds of biologically active monoterpene-derived indole alkaloid (MIA) metabolites and is the sole source ofExpand
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Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism
Summary The extraordinary chemical diversity of the plant-derived monoterpene indole alkaloids, which include vinblastine, quinine, and strychnine, originates from a single biosynthetic intermediate,Expand
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A Pair of Tabersonine 16-Hydroxylases Initiates the Synthesis of Vindoline in an Organ-Dependent Manner in Catharanthus roseus1[C][W]
A newly identified cytochrome P450 isoform initiates the synthesis of valuable alkaloids in leaves of Catharanthus roseus by hydroxylating tabersonine. Hydroxylation of tabersonine at the C-16Expand
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Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids.
Here we report the discovery of a cytochrome P450 that is required for the biosynthesis of vindoline, a plant-derived natural product used for semi-synthesis of several anti-cancer drugs. This enzymeExpand
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Class II Cytochrome P450 Reductase Governs the Biosynthesis of Alkaloids1
Class II cytochrome P450 reductase in Madagascar periwinkle displays a prominent contribution toward specialized metabolism by acting as the main partner of P450s dedicated to alkaloid biosynthesis.Expand
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Inverted stereocontrol of iridoid synthase in snapdragon
The natural product class of iridoids, found in various species of flowering plants, harbors astonishing chemical complexity. The discovery of iridoid biosynthetic genes in the medicinal plantExpand
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Genome and transcriptome guided gene discovery in plant secondary metabolism
Plants produce a wide range of complex secondary metabolites that have many applications, for example as pharmaceutical agents. Gene discovery and the elucidation of these unique biosyntheticExpand