Franziska Hampich

Learn More
Angiotensin (Ang) II promotes renal infiltration by immunocompetent cells in double-transgenic rats (dTGRs) harboring both human renin and angiotensinogen genes. To elucidate disease mechanisms, we investigated whether or not dexamethasone (DEXA) immunosuppression ameliorates renal damage. Untreated dTGRs developed hypertension, renal damage, and 50%(More)
1Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13125 Berlin-Buch, Germany. 2Institute for Biology, University of Lübeck, Ratzeburger Allee 160, D-23538 Lübeck, Germany. 3Institute for Neuropathology, Evangelisches Krankenhaus Bielefeld, Remterweg 2, D-33617 Bielefeld, Germany. 4Center for Nephrology and Hypertension, Ostsee Clinic and(More)
Postischemic acute renal failure (ARF) is common and often fatal. Cellular mechanisms include cell adhesion, cell infiltration and generation of oxygen free radicals, and inflammatory cytokine production. Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors ("statins") directly influence inflammatory mechanisms. The hypothesis that ischemia-induced ARF(More)
  • 1