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A common feature shared by myosin-binding proteins from a wide variety of species is the presence of a variable number of related internal motifs homologous to either the Ig C2 or the fibronectin (Fn) type III repeats. Despite interest in the potential function of these motifs, no group has clearly demonstrated a function for these sequences in muscle,(More)
In the fly Drosophila melanogaster, photoreceptor input to motion vision is split into two parallel pathways as represented by first-order interneurons L1 and L2 (Rister et al., 2007; Joesch et al., 2010). However, how these pathways are functionally specialized remains controversial. One study (Eichner et al., 2011) proposed that the L1-pathway evaluates(More)
Optic flow based navigation is a fundamental way of visual course control described in many different species including man. In the fly, an essential part of optic flow analysis is performed in the lobula plate, a retinotopic map of motion in the environment. There, the so-called lobula plate tangential cells possess large receptive fields with different(More)
Over the last decades, great strides were made in the development of novel implants for the treatment of bone defects. The increasing versatility and complexity of these implant designs request for concurrent advances in means to assess in vivo the course of induced bone formation in preclinical models. Since its discovery, micro-computed tomography(More)
When a service engages in multiple interactions concurrently, it is generally required to correlate incoming messages with messages previously sent or received. Features to deal with this correlation requirement have been incorporated into standards and tools for service implementation, but the supported sets of features are ad hoc as there is a lack of an(More)
A central goal in sensory neuroscience is to fully characterize a neuron's input-output relation. However, strong nonlinearities in the responses of sensory neurons have made it difficult to develop models that generalize to arbitrary stimuli. Typically, the standard linear-nonlinear models break down when neurons exhibit stimulus-dependent modulations of(More)
Reductionist in vitro model systems which mimic specific extracellular matrix functions in a highly controlled manner, termed artificial extracellular matrices (aECM), have increasingly been used to elucidate the role of cell-ECM interactions in regulating cell fate. To better understand the interplay of biophysical and biochemical effectors in controlling(More)
these topologies are difficult to fabricate with other litho-graphic techniques, such as photolithography. [10] Combined with our previous work, [5] which described methods to mold patterned composites of gels, the techniques discussed here allow the formation of structures that incorporate distinct populations of cells within or on the surface of a gel.(More)
Coherent design is a design method for object-oriented software development. It reconciles the requirements of extensibility, comprehensibility, and efficiency for designing reusable libraries. It does so by applying the following principles: separation of behaviour and implementation, compatibility relationships between classes, and conceptual abstraction.(More)