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Certain secretory cells in the hypophysial pars tuberalis of the Djungarian hamster display marked circannual structural alterations. The present investigation deals with the immunohistochemical properties of this cell group. A distinct TSH-like immunoreactivity was found in secretory cells of this type in the pars tuberalis of animals exposed to long(More)
In tissue cultures of male Microtus agrestis, diploid mitoses with two X or two Y chromosomes were found. For identifiying the sex chromosomes in nonhypotonioally treated mitoses, the asynchrony of DNA replication of the sex chromosomes of both sexes was used. The constitutive heterochromatin of Y replicates later in the S period than X, and X2 of the(More)
Different conceptions to revise the licensing regulations for physicians (Approbationsordnung für Ärzte) aim to interlock preclinical and clinical subjects. Therefore a more practice-oriented anatomy has to be taught in basic and postgraduate medical education. At the Westfalian Wilhelms University of Münster we established an interdisciplinary anatomical(More)
In M. agrestis the large heterochromatic sex chromosomes may form heteropycnotic structures of varying size and degree of condensation in interphase nuclei of different tissues. In certain cell types (kidney epithelial cells in vitro, brain cells) the whole sex chromosomes of both sexes form large heteropycnotic chromocenters in interphase. Autoradiographs(More)
In nuclei of the inactive thyroid gland of Microtus agrestis the constitutive heterochromatin is heteropycnotic and forms large chromocenters. After specific activation of the thyroid gland with thyroid stimulating hormone (TSH), or with the thyrostatic methylthiouracil (MTU), an enlargement of cells and nuclei, a high mitotic activity and a despiralization(More)
A method of labelling DNA in vivo with 5-bromodeoxyuridine (BrdU) is described. After 6 h permanent subcutaneous infusion of BrdU in rodents (adult Microtus agrestis, pregnant NMRI-mice), cell nuclei which have undergone DNA synthesis during the BrdU treatment can be differentiated from the nuclei of other cycle stages by means of their altered staining(More)
In kidney epithelial cultures from female Microtus agrestis, 3,55% of all mitoses are multipolar, 94% of them tripolar. Feulgen photometric measurements of 21 tripolar mitoses reveal a total DNA amount corresponding to the mitotic diploid value (4c) in 5 cases, and to the tetraploid value (8c) in 16 cases, Diploid tripolar mitoses divide into one daughter(More)