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Novel synthetic lipid derivatives of poly(ethylene glycol) (PEG) have been synthesized and tested for their ability to decrease uptake of liposomes into the mononuclear phagocyte system (MPS, reticuloendothelial system) in mice and to prolong circulation half-lives of liposomes. A carbamate derivative of PEG-1900 with distearoylphosphatidylethanolamine(More)
The effects of acute treatment with p-chloramphetamine, d-fenfluramine, and reserpine on intracellular (brain tissue and whole blood) and extracellular (CSF and platelet-free plasma) compartments of 5-hydroxytryptamine (5-HT) in the brain and blood of the same rats have been examined. These treatments affected 5-HT in brain tissue and whole blood similarly(More)
Glucose, the principal regulator of endocrine pancreas, has several effects on pancreatic beta cells, including the regulation of insulin release, cell proliferation, apoptosis, differentiation, and gene expression. Although the sequence of events linking glycemia with insulin release is well described, the mechanism whereby glucose regulates nuclear(More)
Taurine is a conditionally essential amino acid for human that is involved in the control of glucose homeostasis; however, the mechanisms by which the amino acid affects blood glucose levels are unknown. Using an animal model, we have studied these mechanisms. Mice were supplemented with taurine for 30 d. Blood glucose homeostasis was assessed by(More)
Specific activation of Ca(2+)-dependent functions is achieved by the particular dynamics and local restriction of Ca(2+) signals. It has been shown that changes in amplitude, duration, or frequency of Ca(2+) signals modulate gene transcription. Thus, Ca(2+) variations should be finely controlled within the nucleus. Although a variety of mechanisms in the(More)
An experiment was conducted to determine the effects of long-term feeding of cottonseed meal on the reproductive traits of Holstein bulls. Holstein bulls approximately 6 mo of age were placed on the following treatments: 1) soybean meal + corn (CON); 2) cottonseed meal + corn (GOS); and 3) cottonseed meal + 4,000 IU vitamin E x bull(-1) x d(-1) (G+4E). The(More)
Reproductive performance of five breeds (81% Holstein or Jersey) in the Florida Agricultural Experiment Station herd was evaluated from data collected over 20 yr. Data represented 1144 parturitions after gestations greater than 250 d with all twin births excluded. Number of services per conception was not affected by age at first insemination. Mean age of(More)
Effects of stage of lactation and pregnancy and their interactions on 17 milk yield and constituent traits of Holsteins and Jerseys were studied. Data were 11,120 Jersey and 11,092 Holstein daily milk samples. After adjustment for all other known and systematic genetic and environmental effects, stage of lactation influenced all traits and accounted for(More)
We have examined the effects of continuous treatment (0.5, 1, 2.5 and 5 mg.kg-1.day-1 for 14 days, using minipumps) with dexfenfluramine (dF) on the concentration of serotonin (5-hydroxytryptamine, 5-HT) in blood, lungs and brain frontal cortex. 5-HT concentration was decreased in whole blood and tissues by the two higher doses (2.5 and 5 mg.kg-1.day-1).(More)