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We consider the problem of estimating a modeling parameter using a weighted least squares criterion (,) = ∑ =1 1 () 2 (() − (,)) 2 for given data by introducing an abstract framework involving generalized measurement procedures characterized by probability measures. We take an optimal design perspective, the general premise (illustrated via examples) being… (More)

The purpose of this paper is to introduce a new spline approximation scheme for retarded functional differential equations. The special feature of this approximation scheme is that it preserves the product space structure of retarded systems and approximates the adjoint semigroup in a strong sense. These facts guarantee the convergence of the solution… (More)

For an infinite-dimensional linear quadratic control problem in Hilbert space, approximation of the solution of the algebraic Riccati operator equation in the strong operator topology is considered under conditions weaker than uniform exponential stability of the approximating systems. As an application, strong convergence of the approximating Riccati… (More)

We present formulations of the Trotter-Kato theorem for approximation of linear C 0-semigroups which provide very useful framework when convergence of numerical approximations to solutions of PDEs are studied. Applicability of our results is demonstrated using a first order hyperbolic equation , a wave equation and Stokes' equation as illustrative examples.

This article examines the functional and clinical impact of time delays that arise in human physiological systems, especially control systems. An overview of the mathematical and physiological contexts for considering time delays will be illustrated, from the system level to cell level, by examining models that incorporate time delays. This examination will… (More)

In this article, we discuss the design and implementation of a receding horizon control (RHC) which will be used to represent the control for the baroreceptor loop in the human cardiovascular system (CVS). This control will be applied to a model of the CVS developed in a previous work by Kappel and Peer. In that earlier work, a linear quadratic control… (More)

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