Franz Hofer

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The RalA and RalB proteins comprise a distinct family of small GTPases [1]. Ral-specific guanine-nucleotide exchange factors such as RalGDS, Rlf and RGL interact with activated Ras and cooperate with Ras in the transformation of murine fibroblasts [2-5]. Thus, the interaction of RalGDS with Ras and the subsequent activation of Ral are thought to constitute(More)
Objective Cryopyrin-associated periodic syndrome (CAPS) is a heterogeneous group of diseases characterized by excessive Interleukin-1b (IL-1 b) release resulting in severe systemic and organ inflammation. Canakinumab targets IL-1b and is approved at standard dose for children and adults with all CAPS phenotypes. Limited data are available regarding(More)
INTRODUCTION Many policy makers and researchers consider knowledge transfer between academia and industry as one of the most promising measures to strengthen economic development. The idea of linking academia and industry is not new. Back in 1910 research universities were established, which strongly emphasized industry-related research as part of their(More)
Background Cryopyrin associated periodic syndrome (CAPS) results from gain-of-function mutations in the NLRP3 gene causing excessive interleukin-1β (IL-1β) release and systemic inflammation. While pathogenic NLRP3 variant phenotypes are well characterized, low-penetrance NLRP3 variants represent a significant clinical challenge. The aims of this study were(More)
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