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- Zbyněk Nový, Alice Lázníčková, Jana Mandíková, Pavel Bárta, Milan Lázníček, František Trejtnar
- Journal of labelled compounds…
- 2014
Monoclonal antibodies are used in the therapy of various diseases. Thanks to their high specific uptake in target tissues, these antibodies can be utilized in targeted radioimmunotherapy as carriers… (More)
- Lucie Švecová, Radim Vrzal, +10 authors Petr Pávek
- Drug metabolism and disposition: the biological…
- 2008
Azole antifungal drug ketoconazole has recently been demonstrated as an inhibitor of a ligand-induced pregnane X receptor (PXR)-mediated transcriptional regulation of the CYP3A4 gene through… (More)
- František Trejtnar, Milan Lázníček
- The quarterly journal of nuclear medicine…
- 2002
Renal excretion is the preferable elimination pathway of radiopharmaceuticals and/or their metabolites from the body. The mechanisms of renal excretion involve glomerular filtration, tubular… (More)
- Kateřina Mačáková, Přemysl Mladěnka, +7 authors Luciano Saso
- Food chemistry
- 2012
Flavonoids, substantial components of the human diet, are generally considered to be beneficial. However, they may possess possible pro-oxidative effects, which could be based on their reducing… (More)
- Věra Štětinová, František Trejtnar, +4 authors V Semecký
- Journal of pharmacological and toxicological…
- 1996
The method of determination of the minute excretion of tubular epithelial cells renders it possible to investigate the course of the nephrotoxic effect of the toxin by the influence of which… (More)
- Jana Mandíková, Marie Volková, +4 authors František Trejtnar
- Toxicology
- 2013
Members of acyclic nucleoside phosphonates (ANPs) possess antiviral and antiproliferative activities. However, several clinically important ANPs may cause renal injury, most likely due to their… (More)
- Marie Volková, Jana Mandíková, Alice Lázníčková, Milan Lázníček, Pavel Bárta, František Trejtnar
- Nuclear medicine and biology
- 2015
INTRODUCTION
Radiolabeled receptor-targeting peptides are a useful tool for the diagnostic imaging and radiotherapy of some malignancies. However, the retention of radioactivity in the kidney may… (More)
- Ján Kozic, Eva Novotná, Marie Volková, Jiřina Stolaříková, František Trejtnar, Jarmila Vinšová
- European journal of medicinal chemistry
- 2012
A new series of N-(3/4-substituted phenyl) 4/5-chloro-2-methoxybenzamides and their thioxo analogues have been synthesised and evaluated for in vitro antimycobacterial activity against Mycobacterium… (More)
- Lucie Hyršová, Alena Vanduchova, +8 authors Petr Pávek
- Toxicology letters
- 2019
Resveratrol (RSV) is a stilbene phytochemical common in food and red wine. RSV inhibits cytochrome P450 CYP3A4 activity and interacts with the pregnane X receptor (PXR), the central regulator of… (More)
- Ondřej Soukup, Daniel Jun, +13 authors Kamil Kuča
- Current Alzheimer research
- 2013
Alzheimer´s disease (AD) is a progressive neurodegenerative dementia which currently represents one of the biggest threats for the human kind. The cure is still unknown and various hypotheses… (More)