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A series of 3,4-methylenedioxy-N-alkylamphetamines (MDAAs) were automatically docked and subjected to molecular dynamics (MD) simulations in a cytochrome P450 2D6 (CYP2D6) protein model. The… (More)
Alders, David J. C., A. B. Johan Groeneveld, Frans J. J. de Kanter, and Johannes H. G. M. van Beek. Myocardial O2 consumption in porcine left ventricle is heterogeneously distributed in parallel to… (More)
Mutants of bacterial cytochrome P450 BM3 from Bacillus megaterium have gained increasing interest to support drug metabolism studies by producing human relevant biotransformation products and/or to… (More)
A short and efficient synthesis of the important drug candidate telaprevir (IX), featuring a biocatalytic desymmetrization and two multicomponent reactions as the key steps is presented.
Highly functionalized and conformationally constrained depsipeptides based on a dihydropyridin-2-one core are prepared by the combination of a four- and a three-component reaction. The synthesis… (More)
Oxidation-hydrocyanation of γ,δ-unsaturated alcohols using (immobilised) TEMPOXPhI(OAc)2 in combination with HbHNL proceeds smoothly. After (in situ) protection, the resulting cyanohydrin derivatives… (More)
Biradical CIDNP observed in the title reaction indicates that two intersystem-crossing mechanisms are operative in the intermediate 1,4-biradical, one involving hyperfine coupling of the odd… (More)
The combination of the recently developed multicomponent construction of highly substituted 3,4-dihydropyridones with subsequent allylation and intramolecular Heck-type cyclization allows the… (More)
3,4-cis-substituted imines, such as (I), prepared via biocatalytic desymmetrization as reported earlier, are used as imine components in an Ugi-type multicomponent reaction.