Frans Hochstenbach

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The T cell receptor (TCR) delta protein is expressed as part of a heterodimer with TCR gamma, in association with the CD3 polypeptides on a subset of functional peripheral blood T lymphocytes, thymocytes, and certain leukemic T cell lines. A monoclonal antibody directed against TCR delta was produced that binds specifically to the surface of several TCR(More)
A subpopulation of peripheral blood T lymphocytes express a novel non-a, non-0 T cell receptor (TCR) heterodimer that is associated with the CD3 complex. This heterodimer is composed of TCRy and TCRS polypeptides which are distinct from each other on the basis of immunochemical criteria (1-3) and by peptide mapping (4), and are encoded by different genes.(More)
B cell chronic lymphocytic leukemia (CLL), the most common leukemia in adults, is a clonal expansion of CD5(+)CD19(+) B lymphocytes. Two types of CLLs are being distinguished as carrying either unmutated or somatically mutated immunoglobulins (Igs), which are associated with unfavorable and favorable prognoses, respectively. More than 30% of CLLs can be(More)
Specific monoclonal antibodies have made possible the identification of two T-cell antigen receptor (TCR) heterodimers, alpha beta TCR and gamma delta TCR. Formation of these receptors is largely separated by the preferential pairing of alpha-TCR with beta and gamma-TCR with delta, the sequential rearrangement and expression of the TCR loci during thymic(More)
To explore the conservation of Src homology 3 (SH3) domain-mediated networks in evolution, we compared the specificity landscape of these domains among four yeast species, Saccharomyces cerevisiae, Ashbya gossypii, Candida albicans, and Schizosaccharomyces pombe, encompassing 400 million years of evolution. We first aligned and catalogued the families of(More)
The specificity ofT lymphocytes derives from the properties ofclonally distributed membrane receptors. For most peripheral T cells (CD4+ CD8-and CD4-CD8+), antigen is corecognized with molecules of the MHC by a receptor consisting ofclonally diverse aR heterodimers associated with the multichain CD3 complex (1-3). Recently, a subpopulation ofT cells was(More)
We characterized a novel extracellular matrix element that is present in the earliest developmental stages of Xenopus laevis, and is recognized by an mAb 3D7. Based on amino acid composition, breakdown patterns by bacterial collagenases, and the molecular weights of the components of the antigen (240, 200, and 140 kD), we found it very similar to mammalian(More)
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