Frans B.L. Hogervorst

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UNLABELLED Mutations in BRCA1 and BRCA2 account for the majority of hereditary breast and ovarian cancers, and therefore sequence analysis of both genes is routinely conducted in patients with early-onset breast cancer. Besides mutations that clearly abolish protein function or are known to increase cancer risk, a large number of sequence variants of(More)
chapter Chapter 6: Uptake of PND for Rb and other hereditary cancer syndromes 111 Uptake of prenatal diagnostic testing for retinoblastoma compared to other hereditary cancer syndromes Submitted 6 6 112 Chapter 6: Uptake of PND for Rb and other hereditary cancer syndromes abstRact background The genetic cause of many hereditary cancer syndromes has been(More)
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract 1 2 Mutations in BRCA1 and BRCA2 account for the majority of hereditary breast and ovarian 3 cancers, and therefore sequence analysis of both genes is routinely performed in patients 4 with early-onset breast cancer. Besides mutations that clearly(More)
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