Frank W. McKee

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Constriction of inferior vena cava above the diaphragm is used to produce experimental ascites in the dog. This type of experimental ascites drains the body protein reserves, reduces the level of circulating plasma proteins, and in effect is an internal plasmapheresis. As the ascitic fluid is withdrawn and the proteins measured, we observe a production of(More)
Ascitic fluid as it accumulates in animals or man is generally looked upon as a stagnant pool which contains protein, but is not an active part of the body protein pool. The experiments described below indicate a rapid exchange of protein between the ascitic pool and the circulating plasma--protein moves from the plasma into the ascitic pool and from the(More)
Intraperitoneal injection of red cells tagged with radioiron into dogs with experimental ascites demonstrated that such cells were rapidly transferred into the circulating blood. When the experimental animals were not actively producing ascitic fluid, 43.4, 67.0, and 56.4 per cent respectively, of the administered radioactive red cells passed to the blood(More)
After plasma containing labeled plasma protein has been given intraperitoneally to dogs with experimental ascites a steady and rather rapid movement takes place of the labeled protein into the circulating blood. When plasma containing labeled plasma protein has been injected intravenously into the ascitic dog the labeled protein steadily disappears from the(More)
Previous studies (1-6) of experimental ascites primarily concerned with protein metabolism and exchange have emphasized the importance of sodium in ascitic fluid production. Recently, the importance of sodium retention in several forms of effusions and edema has been described by numerous observers (7-15) who have all directly or indirectly implicated the(More)