Frank Subke

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Recently, methods have been developed for the isolation of expressed sequences from particular human chromosomes. Using Alu consensus sequences as primers, cDNA synthesis has been initiated from interspecies hybrid cell lines that contain single human chromosomes. Alu consensus sequences have also been utilized to amplify human genomic sequences via(More)
Multiple endocrine neoplasia type 2A (MEN2A), a dominantly inherited cancer syndrome, is defined by the presence of medullary thyroid carcinoma (MTC), pheochromocytoma (pheo), and primary hyperparathyroidism (p-HPT). Along with multiple endocrine neoplasia type 2B (MEN2B) and familial medullary thyroid carcinoma (FMTC), it is associated with germline(More)
Loss of one copy of chromosome 22 is the most prevalent chromosomal change in meningioma, indicative of a tumor suppressor on chromosome 22. Meningioma retaining both copies of chromosome 22 could be possibly be explained by isodisomy for a meningioma suppressor gene. To investigate whether the chromosomal situation in meningioma is consistent with this(More)
DELETIONS AT THE EXONIlINTRONI BOUNDARY OF THE EGF-R GENE AND PRIMARY BREAST CANCER PROGRESSION. B.Brandt, F. Gebhardt, U. Vogt, D. Schuster*, J. Beck*, A. MSller**, K.S. Z~nker, G. Assmann. The importance of epidermal growth factor receptor (EGF-R) expression for metastatic growth was dlscoverd in several experimental and clinical studies. The(More)
In an approach to identify new candidates for tumor related genes, a set of established and new polymorphic DNA markers (simple sequence repeats) was used in menigioma samples to test for deletions within human chromosome 22. For this purpose, cytogenetically well characterized tumors were applied and those with monosomy #22 were omitted; only disomic(More)
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