Frank Skidmore

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OBJECTIVE This investigation sought to study immediate and delayed verbal and visuospatial recall in Parkinson disease (PD) patients with left hemibody (LHO) and right hemibody (RHO) onset of motor symptoms and to examine the role of mental processing speed in recall of this information. BACKGROUND Research is mixed regarding material specific memory(More)
BACKGROUND/OBJECTIVES Patients with Parkinson disease (PD) exhibit motor and frontal-executive dysfunction and often seem to be emotionally apathetic. We investigated whether PD patients have alterations in their emotional reactivity and how this might impact their proximal (avoidance) versus distal (approach) allocation of attention-intention. METHODS(More)
The Analysis of Functional Neuroimaging (AFNI) suite [1], a set of C programs and auxiliary scripts for processing, analyzing, and displaying functional Magnetic Resonance Imaging (fMRI) data (a technique for mapping human brain activity), is a widely adopted open-source tool in the MRI data analysis community. For many types of analysis pipelines, a key(More)
In the study of Parkinson's disease (PD), substantial research has shown a variety of findings within brain MR images that differ on a group-wise level between individuals with PD and healthy adults, including resting brain activity and blood flow [1, 2], diffusion tensor fractional anisotropy [3], and brain iron deposition [4, 5]. Despite these promising(More)
Whereas the left hemisphere is involved in regulating the parasympathetic nervous system, the right hemisphere regulates the sympathetic. Given the asymmetrical onset of motor symptoms and neuropathology in PD, differences in cardiovascular functions might be expected between PD patients with left hemibody onset (LHO) versus right hemibody onset (RHO). A(More)
Due to motor and neuropathological asymmetries, Parkinson's disease (PD) patients with right hemibody onset (RHO) of symptoms may experience greater benefit from dopaminergic enhancing medications, relative to patients with left hemibody onset (LHO). We investigated this possibility by measuring UPDRS scores of 20 PD patients with LHO and 13 patients with(More)
Camptocormia describes a severe forward-flexion at the waist. Originally used in reference to a conversion disorder seen in military personel (Souques and Rosanoff-Saloff, Rev Neurol 1915, 22, 937; Rosen and Frymoyer, Spine 1985, 10, 325; Miller and Forbes, Br J Psychiatry 1990, 157, 765; Perez-Sales, Arch Phys Med Rehabil 1990, 71, 1078; Sinel and(More)
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