Learn More
BACKGROUND AND PURPOSE Depression occurs frequently in PD; however the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural changes in the thalamus of patients with DPD compared with those with NDPD. MATERIALS AND METHODS FA and MD maps from DTI were obtained(More)
Transcription factors are fate determining regulatory factors in dopaminergic neuronal development and differentiation. Among them, Nurr1 is the most extensively studied, but the importance of Pitx3 has recently been appreciated. Over-expression of both factors has been utilized to enhance the dopaminergic differentiation of stem cells for transplantation(More)
Recent studies have shown that aging, psychiatric and neurologic diseases, and dopaminergic blockade all result in altered brain network efficiency. We investigated the efficiency of human brain functional networks as measured by fMRI in individuals with idiopathic Parkinson's disease (N=14) compared to healthy age-matched controls (N=15). Functional(More)
Acute vertebrobasilar dissection may cause subarachnoid hemorrhage by rupturing through the adventia or cerebral infarct by progressive occlusion of the true lumen. Recent reports on the endovascular management of this condition have focused on treatment of pseudoaneurysms. We report two cases where angioplasty or stent placement was successfully used to(More)
In the study of Parkinson's disease (PD), substantial research has shown a variety of findings within brain MR images that differ on a group-wise level between individuals with PD and healthy adults, including resting brain activity and blood flow [1, 2], diffusion tensor fractional anisotropy [3], and brain iron deposition [4, 5]. Despite these promising(More)
The Analysis of Functional Neuroimaging (AFNI) suite [1], a set of C programs and auxiliary scripts for processing, analyzing, and displaying functional Magnetic Resonance Imaging (fMRI) data (a technique for mapping human brain activity), is a widely adopted open-source tool in the MRI data analysis community. For many types of analysis pipelines, a key(More)
  • 1