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  • Johannes Plank, Manfred Bodenlenz, +7 authors Thomas R. Pieber
  • Medicine
  • Diabetes care
  • 2005 (First Publication: 1 May 2005)
  • OBJECTIVE To investigate the pharmacodynamic profile and duration of action for five subcutaneous doses of insulin detemir (0.1, 0.2, 0.4, 0.8, and 1.6 units/kg; 1 unit = 24 nmol) and oneExpand
  • Andrea Wutte, Johannes Plank, +6 authors Thomas R. Pieber
  • Medicine
  • Experimental and clinical endocrinology…
  • 2007 (First Publication: 23 July 2007)
  • AIMS This study was conducted to evaluate the dose ratio of insulin detemir and neutral protamine Hagedorn (NPH) insulin over a range of therapeutically relevant subcutaneous doses. METHODS TheExpand
  • Manfred Bodenlenz, Lukas Schaupp, +6 authors Thomas R. Pieber
  • Biology, Medicine
  • American journal of physiology. Endocrinology and…
  • 2005 (First Publication: 1 August 2005)
  • Insulin's action to stimulate glucose utilization is determined by the insulin concentration in interstitial fluid (ISF) of insulin-sensitive tissues. The concentration of interstitial insulin hasExpand
  • Thomas Birngruber, Arijit Ghosh, +4 authors Frank Sinner
  • Medicine, Chemistry
  • Clinical and experimental pharmacology…
  • 2013 (First Publication: 1 December 2013)
  • The blood-brain barrier (BBB) limits substance transport to the brain and is therefore the major hurdle to overcome when developing neuroactive drugs. Herein, we report on cerebral open flowExpand