Frank Schuhmacher

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The Sharpe ratio is adequate for evaluating investment funds when the returns of those funds are normally distributed and the investor intends to place all his risky assets into just one investment fund. Hedge fund returns differ significantly from a normal distribution. For this reason, other performance measures for hedge fund returns have been proposed(More)
BACKGROUND & AIMS Diagnostic procedures in Whipple's disease usually focus on the intestine, but symptomatic central nervous system involvement is a major threat for patients. The aim of this study was to determine the diagnostic value of cerebrospinal fluid (CSF) analysis. METHODS A total of 39 CSF samples and 2 brain biopsy specimens that were obtained(More)
Whipple's disease is a systemic disorder in which a gram-positive rod-shaped bacterium is constantly present in infected tissues. After numerous unsuccessful attempts to culture this bacterium, it was eventually characterized by 16S rRNA gene analysis to be a member of the actinomycetes. The name Tropheryma whippelii was proposed. Until now, the bacterium(More)
Monoclonal antibodies that recognize plant cell wall glycans are used for high-resolution imaging, providing important information about the structure and function of cell wall polysaccharides. To characterize the binding epitopes of these powerful molecular probes a library of eleven plant arabinoxylan oligosaccharides was produced by automated solid-phase(More)
In this paper, deformations of L∞-algebras are defined in such a way that the bases of deformations are L∞-algebras, as well. A universal and a semiuniversal deformation is constructed for L∞-algebras, whose cotangent complex admits a splitting. The paper also contains an explicit construction of a minimal L∞-structure on the homology H of a differential(More)
This paper explores the consequences of imposing a formal provability requirement on rational belief formation in normal-form games. Speci ̄cally, we consider the hypothesis that a player assigns positive probability to a strategy pro ̄le if and only if it is provable that the component strategies of the pro ̄le are possibly chosen by the other players. It(More)
Performance measurement is an integral part of investment analysis and risk management. The goal of performance measurement is to build a ranking of different investments on the basis of risk-adjusted returns in order to evaluate the relative success of these investments. The Sharpe Ratio is the best-known measure of this type. It considers the first two(More)
Lactotetraosyl (Lc4) and neo-lactotetraosyl (nLc4) are backbones that are common to many glycans. Using automated glycan assembly, these common core structures were constructed and elaborated to access synthetically challenging glycans of biological relevance. The incorporation of α-fucoses is demonstrated for H-type I and II; α(1,3)-galactose epitopes were(More)