Frank Schröder

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Overexpression and activation of protein kinase C-epsilon (PKCepsilon) results in myocardial hypertrophy. However, these observations do not establish that PKCepsilon is required for the development of myocardial hypertrophy. Thus, we subjected PKCepsilon-knockout (KO) mice to a hypertrophic stimulus by transverse aortic constriction (TAC). KO mice show(More)
Despite saturation of nitric oxide (NO) synthase (NOS) by its substrate l-arginine (Arg), oral and intravenous supplementation of Arg may enhance NO synthesis, a phenomenon known as “The l-arginine paradox”. Yet, Arg is not only a source of NO, but is also a source for guanidine-methylated (N G) arginine derivatives which are all inhibitors of NOS activity.(More)
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SYNOPSIS The advantage of establishing routine collaboration between European national and multinational agencies to maximise benefits from operational monitoring programmes has been recognised by EuroGOOS. However, in practice, such collaboration has proven difficult to establish and sustain, partially as a result of funding constraints. Nevertheless as(More)
Energy-dependent patterns in the arrival directions of cosmic rays are searched for using data of the Pierre Auger Observatory. We investigate local regions around the highest-energy cosmic rays with E ≥ 6×10 19 eV by analyzing cosmic rays with energies above E ≥ 5×10 18 eV arriving within an angular separation of approximately 15 •. We characterize the(More)
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